Nokea
Conjunctivitis in a child that is accompanied by acute otitis media is treated with:
- A. Sulfacetamide 10% ophthalmic solution (Bleph-10)
- B. Bacitracin/polymyxin B (Polysporin) ophthalmic drops
- C. Ciprofloxacin (Ciloxan) ophthalmic drops
- D. High-dose oral amoxicillin
Correct Answer: D
Rationale: Conjunctivitis with otitis suggests bacterial cause (e.g., H. influenzae), treated with oral amoxicillin.
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Drug efficacy' refers to..
- A. The range of diseases in which the drug is beneficial
- B. The maximal intensity of response that can be produced by the drug
- C. The therapeutic dose range of the drug
- D. The therapeutic index of the drug
Correct Answer: B
Rationale: Efficacy is defined as the maximum effect a drug can produce, per pharmacological principles.
The U.S. Food and Drug Administration regulates:
- A. Prescribing of drugs by MDs and NPs
- B. The official labeling for all prescription and over-the-counter drugs
- C. Off-label recommendations for prescribing
- D. Pharmaceutical educational offerings
Correct Answer: B
Rationale: The FDA regulates drug labeling , not prescribing practices , off-label use , or education , which fall under state or professional domains.
Choose a drug that is used for both non-Hodgkin's lymphoma and rheumatoid arthritis:
- A. Doxorubicin
- B. Vincristine
- C. Infliximab
- D. Rituximab
Correct Answer: D
Rationale: Rituximab targets CD20 in lymphoma and is also used in rheumatoid arthritis.
Before prescribing phentermine to Sarah, a thorough drug history should be taken including assessing for the use of serotonergic agents such as selective serotonin reuptake inhibitors (SSRIs) and St John's wort due to:
- A. Additive respiratory depression risk
- B. Additive effects affecting liver function
- C. The risk of serotonin syndrome
- D. The risk of altered cognitive functioning
Correct Answer: C
Rationale: Phentermine with serotonergic agents increases serotonin syndrome risk.
While administering a medication that the nurse has researched and found to have limited effectiveness, the patient tells the nurse, I have read all about this drug and it is such a wonder drug. I'm so lucky my doctor prescribed it because I just know it will treat my problem. The nurse suspects this drug will be more effective than usual for this patient because of what effect?
- A. Cumulative effect
- B. First-pass effect
- C. Placebo effect
- D. Cross-tolerance effect
Correct Answer: C
Rationale: A drug is more likely to be effective if the patient thinks it will work than if the patient believes it will not work. This is called the placebo effect. If a drug is taken in successive doses at intervals that are shorter than recommended, or if the body is unable to eliminate a drug properly, the drug can accumulate in the body, leading to toxic levels and adverse effects. This is a cumulative effect. First-pass effect addresses the reduction of available drug when taken orally due to metabolism in the liver before the drug reaches the bloodstream. Cross-tolerance is resistance to drugs within the same class.