Questions on Gastrointestinal Tract Related

Review Questions on Gastrointestinal Tract related questions and content

Corticosteroid medications are associated with the development of peptic ulcers because of which probable pathophysiologic mechanism?

  • A. The enzyme urease is produced.
  • B. Secretion of hydrochloric acid is increased.
  • C. The rate of mucous cell renewal is decreased.
  • D. The synthesis of mucus and prostaglandins is inhibited.
Correct Answer: D

Rationale: The correct answer is D because corticosteroids inhibit the synthesis of mucus and prostaglandins, which are important for protecting the stomach lining. Without enough mucus and prostaglandins, the stomach lining becomes more susceptible to damage from stomach acid, leading to the development of peptic ulcers.

Choice A is incorrect because the enzyme urease is associated with the development of Helicobacter pylori infection, not peptic ulcers directly. Choice B is incorrect because corticosteroids actually decrease hydrochloric acid secretion. Choice C is incorrect because a decreased rate of mucous cell renewal would lead to decreased mucus production, which could contribute to peptic ulcers, but it is not the primary mechanism associated with corticosteroids.