Dexmedetomidine:
Correct Answer: C
Rationale: Dexmedetomidine is a highly selective α₂-adrenergic receptor agonist, not αâ‚, used for sedation with minimal respiratory depression. It reduces the minimum alveolar concentration of volatile anesthetics by enhancing sedation and analgesia, not increasing it. Bradycardia is a well-known side effect due to its sympatholytic action, decreasing heart rate via vagal stimulation and reduced catecholamine release. The standard loading dose is indeed 0.5-1.0 μg kgâ»Â¹ over 10 minutes, followed by infusion, aligning with clinical protocols. At high infusion rates, respiratory depression is unlikely, distinguishing it from opioids. Bradycardia's prominence as a side effect stems from its mechanism activation of α₂ receptors in the brainstem and periphery inhibits sympathetic outflow, making it a critical consideration in perioperative management, especially in patients with cardiovascular comorbidities.
Nokea