Nokea
Diabetes Insipidus is a deficiency of what hormone?
- A. Atrial Natriuretic Peptide
- B. Vasopressin
- C. Aldosterone
- D. Insulin
Correct Answer: B
Rationale: Diabetes Insipidus is a condition characterized by the body's inability to properly regulate water balance, leading to excessive urination and extreme thirst. This disorder is caused by a deficiency of vasopressin, also known as antidiuretic hormone (ADH). Vasopressin is a hormone produced by the hypothalamus and released by the pituitary gland to help regulate water balance in the body by controlling the amount of water reabsorbed by the kidneys. The lack of vasopressin in Diabetes Insipidus results in the kidneys producing a large volume of dilute urine, leading to dehydration and electrolyte imbalances.
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Which one of the following is acromegaly caused by?
- A. Overproduction of adrenocorticotropic hormone (ACTH)
- B. Overproduction of gonadotrophin releasing hormone (GnRH)
- C. Overproduction of growth hormone (GH)
- D. Overproduction of vasopressin (antidiuretic hormone)
Correct Answer: C
Rationale: Acromegaly is a disorder that is characterized by the overproduction of growth hormone (GH) by the pituitary gland in adults. This results in the abnormal growth of bones and tissues, leading to enlarged hands, feet, and facial features. The excess GH is usually caused by a pituitary tumor known as a somatotroph adenoma. This tumor causes the pituitary gland to produce excessive amounts of GH, which in turn leads to the symptoms associated with acromegaly. Treatment for acromegaly often involves surgical removal or reduction of the pituitary tumor, as well as medication to normalize GH levels.
Which of the following causes of Cushing's syndrome does the phrase "Cushing's disease" specifically refer to?
- A. Iatrogenic
- B. Ectopic ACTH production
- C. Pituitary adenoma
- D. Adrenal adenoma
Correct Answer: C
Rationale: The phrase "Cushing's disease" specifically refers to the cause of Cushing's syndrome that is due to an ACTH-secreting pituitary adenoma. In this specific case, the excess production of ACTH leads to bilateral adrenal hyperplasia and oversecretion of cortisol. It is important to differentiate between Cushing's syndrome caused by a pituitary adenoma (Cushing's disease) and other causes such as adrenal adenomas, ectopic ACTH production, or iatrogenic sources.
Which of the following hormones are stored in the posterior pituitary gland?
- A. Prolactin
- B. Thyroid stimulating hormone (TSH)
- C. Growth hormone (GH)
- D. Adrenocorticotropic hormone (ACTH)
Correct Answer:
Rationale: Oxytocin and Vasopressin, also known as antidiuretic hormone (ADH), are the hormones stored in the posterior pituitary gland. These hormones are produced by the hypothalamus and then transported and stored in the posterior pituitary gland until they are released into the bloodstream when needed. Oxytocin plays a role in uterine contractions during childbirth and milk ejection during lactation, while Vasopressin regulates water balance in the body by acting on the kidneys to reduce urine production and conserve water. The other hormones listed, such as Prolactin, TSH, GH, ACTH, FSH, and LH, are produced by the anterior pituitary gland.
Karyotype 47, XYY is:
- A. True hermaphroditism
- B. Supermale
- C. Klinefelter's syndrome
- D. Gonadal dysgenesis
Correct Answer: B
Rationale: Karyotype 47, XYY refers to the presence of an extra Y chromosome in males. This condition is known as XYY syndrome, also called Jacob's syndrome. Individuals with XYY syndrome are typically phenotypically male but may have some associated physical and behavioral characteristics. These individuals are often referred to as "supermales" due to the presence of the extra Y chromosome. This is different from true hermaphroditism, Klinefelter's syndrome, and gonadal dysgenesis, which have distinct chromosomal patterns and manifestations.
Enlargement of the bones of the hands, feet, and face due to overproduction of growth hormone is called :
- A. Acromegaly
- B. Cushing syndrome
- C. Gigantism
- D. Myxedema
Correct Answer: A
Rationale: Acromegaly is the condition characterized by the enlargement of the bones of the hands, feet, and face due to the overproduction of growth hormone in adults. This excess growth hormone typically comes from a benign tumor in the pituitary gland, leading to the gradual enlargement of these body parts. Cushing syndrome, on the other hand, is caused by prolonged exposure to high levels of cortisol and is not directly related to bone enlargement. Gigantism is the condition of excessive growth in height due to overproduction of growth hormone occurring in children before the closure of growth plates. Myxedema is a term used to describe severe hypothyroidism and is not directly associated with bone enlargement.