Nokea
Direct renin inhibitors have the following properties. They:
- A. Are primarily generic drugs
- B. Are a renin-angiotensin-aldosterone system (RAAS) medication that is safe during pregnancy
- C. Can be used with an angiotensin-converting enzyme and angiotensin II receptor blocker medications for stronger impact
- D. Shut down' the entire RAAS cycle
Correct Answer: C
Rationale: Direct renin inhibitors (e.g., aliskiren) can be combined with ACEIs or ARBs for enhanced RAAS blockade.
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Which of the following would be the best source of drug information for a nurse?
- A. Drug Facts and Comparisons book
- B. A nurse's drug guide
- C. A drug package insert
- D. The Physician's Drug Reference (PDR)
Correct Answer: B
Rationale: The most user-friendly drug source for a nurse is a nurse's drug guidebook. A guide provides nursing implications and patient teaching points that are most useful to nurses. The Drug Facts and Comparisons book provides a wide range of drug information but is hard to manipulate and is very expensive. A package insert contains all of the chemical and drug company research information about a drug, however, the information can be difficult to understand and the print is very small. The PDR is heavily cross-referenced and difficult to use.
Tick the second messenger of G-protein-coupled (metabotropic) receptor:
- A. Adenylyl cyclase
- B. Sodium ions
- C. Phospholipase C
- D. cAMP
Correct Answer: D
Rationale: cAMP is a classic second messenger generated by G-protein-coupled receptors via adenylyl cyclase.
Effects of glucagon are:
- A. Positive inotropic and chronotropic effects
- B. Negative inotropic and chronotropic effects
- C. Inhibition of Gs protein and decrease of CAMP
- D. Activation of Gq and accumulation of Inositol triphosphate
Correct Answer: A
Rationale: Glucagon has positive inotropic and chronotropic effects on the heart, increasing contractility and rate.
Anti-inflammatory action of glucocorticoids is determined by:
- A. Inhibition of phospholipase A2
- B. Activation of phospholipase A2
- C. Inhibition of cyclooxygenase type-1
- D. Inhibition of cyclooxygenase type-2
Correct Answer: A
Rationale: Glucocorticoids inhibit phospholipase A2, reducing the production of inflammatory mediators like prostaglandins.
Which of the following patients would be at higher risk of experiencing adverse drug reactions (ADRs):
- A. A 32-year-old male
- B. A 22-year-old female
- C. A 3-month-old female
- D. A 48-year-old male
Correct Answer: C
Rationale: Infants like a 3-month-old have immature organ systems, increasing ADR risk compared to healthy adults.