Nokea
Drugs mostly cross biological membranes by
- A. Passive diffusion
- B. Active diffusion
- C. Active transport
- D. Carrier mediated transport
Correct Answer: A
Rationale: Most drugs cross membranes via passive diffusion based on concentration gradients.
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A nurse is caring for a patient who has been receiving a drug by the intramuscular route but will receive the drug orally after discharge. How does the nurse explain the increased dosage prescribed for the oral dose?
- A. Passive diffusion
- B. Active transport
- C. Glomerular filtration
- D. First-pass effect
Correct Answer: D
Rationale: The first-pass effect involves drugs that are absorbed from the small intestine directly into the portal venous system, which delivers the drug molecules to the liver. After reaching the liver, enzymes break the drug into metabolites, which may become active or may be deactivated and readily excreted from the body. A large percentage of the oral dose is usually destroyed and never reaches tissues. Oral dosages account for the phenomenon to ensure an appropriate amount of the drug in the body to produce a therapeutic action. Passive diffusion is the major process through which drugs are absorbed into the body. Active transport is a process that uses energy to actively move a molecule across a cell membrane and is often involved in drug excretion in the kidney. Glomerular filtration is the passage of water and water-soluble components from the plasma into the renal tubule.
Which of the following is true regarding the Dietary Supplement Health and Education Act (DSHEA)?Select one that does not apply.
- A. The act allows for DEA enforcement of the act.
- B. The act gives the FDA power to enforce the laws governed by the act.
- C. The act permits general health claims.
- D. The act does not permit curative health claims.
Correct Answer: A
Rationale: The DSHEA defines substances such as herbs, vitamins, minerals, amino acids, and other natural substances as 'dietary supplements' and permits general health claims as long as the label also has a disclaimer stating that the supplements are not approved by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. The act gives the FDA the power to enforce the laws governed by the act.
The nurse is conducting an admission assessment on a patient. When collecting data related to medications the nurse asks, What medications are you currently taking? After collecting this information, what other questions should the nurse ask?
- A. Do you take any medications?
- B. What over-the-counter (OTC) medications do you take?
- C. Do you take gym sessions?
- D. Do you take medications safely when you take them?
Correct Answer: B
Rationale: OTC meds and supplements can affect therapy; 'current medications' already covers A, and D is vague.
The decision may be made to switch from twice daily neutral protamine Hagedorn (NPH) insulin to insulin glargine to improve glycemia control throughout the day. If this is done:
- A. The initial dose of glargine is reduced by 20% to avoid hypoglycemia
- B. The initial dose of glargine is 2 to 10 units per day
- C. Patients who have been on high doses of NPH will need tests for insulin antibodies
- D. Obese patients may require more than 100 units per day
Correct Answer: A
Rationale: Switching to glargine reduces the dose by 20% to prevent hypoglycemia due to its steady action vs. NPH peaks.
The U.S. Food and Drug Administration approval is required for:
- A. Medical devices, including artificial joints
- B. Over-the-counter vitamins
- C. Herbal products, such as St John's wort
- D. Dietary supplements, such as Ensure
Correct Answer: A
Rationale: FDA approval is required for medical devices like artificial joints , but not OTC vitamins, herbal products, or supplements (B-D), which have lighter oversight.