Nokea
Drugs needed for diseases with fewer than 200,000 patients, and that fail to receive attention for development because of cost and need, are called:
- A. secondary drugs
- B. minor drugs
- C. orphan drugs
- D. specialty drugs
Correct Answer: C
Rationale: The correct answer is C: orphan drugs. Orphan drugs are medications developed to treat rare diseases affecting fewer than 200,000 patients. These diseases often lack attention from pharmaceutical companies due to the high cost and limited market potential. Orphan drugs receive special incentives and regulatory support to encourage their development.
A: Secondary drugs do not specifically refer to medications for rare diseases.
B: Minor drugs is not a recognized term in the context of rare disease medications.
D: Specialty drugs typically refer to high-cost medications used to treat complex or chronic conditions, but not necessarily rare diseases.
You may also like to solve these questions
A patient with a sore throat and fever had a throat smear stained with Gram's method, revealing Gram-positive cocci in chains. What is the most likely causative agent?
- A. Streptococcus pyogenes
- B. Staphylococcus aureus
- C. Neisseria gonorrhoeae
- D. Enterococcus faecalis
Correct Answer: A
Rationale: The correct answer is A: Streptococcus pyogenes. This bacterium is known to cause sore throat and fever, commonly referred to as strep throat. Gram's stain showing Gram-positive cocci in chains is characteristic of Streptococcus species. Streptococcus pyogenes is a beta-hemolytic bacterium that forms chains and is a common cause of bacterial pharyngitis. Staphylococcus aureus (B) is a Gram-positive cocci that forms clusters, not chains. Neisseria gonorrhoeae (C) is a Gram-negative diplococcus and is not associated with sore throat. Enterococcus faecalis (D) is a Gram-positive cocci that can cause infections but is not typically associated with sore throat.
A wound culture revealed Gram-negative rods that are lactose non-fermenters. The bacteria were isolated from a patient with a deep tissue infection. What is the most likely microorganism?
- A. Pseudomonas aeruginosa
- B. Escherichia coli
- C. Salmonella typhi
- D. Shigella dysenteriae
Correct Answer: A
Rationale: The correct answer is A: Pseudomonas aeruginosa. P. aeruginosa is a Gram-negative rod that is a lactose non-fermenter commonly associated with deep tissue infections. It is an opportunistic pathogen known for its ability to cause infections in immunocompromised individuals. P. aeruginosa is often resistant to multiple antibiotics and can form biofilms, making it difficult to treat.
Summary of why other choices are incorrect:
B: Escherichia coli is a Gram-negative rod that ferments lactose and is commonly found in the gastrointestinal tract. It is not typically associated with deep tissue infections.
C: Salmonella typhi is a Gram-negative rod that causes typhoid fever, primarily affecting the gastrointestinal system, not deep tissue infections.
D: Shigella dysenteriae is a Gram-negative rod that causes bacillary dysentery, which primarily affects the gastrointestinal tract and does not typically cause deep tissue infections.
A wound culture from a patient with an infected ulcer revealed Gram-positive rods with terminal spores. What is the most likely causative agent?
- A. Clostridium perfringens
- B. Bacillus anthracis
- C. Clostridium tetani
- D. Bacillus cereus
Correct Answer: A
Rationale: Step-by-step rationale:
1. Gram-positive rods with terminal spores suggest Clostridium genus.
2. Terminal spores are characteristic of Clostridium perfringens.
3. C. perfringens is known to cause wound infections.
4. Therefore, the most likely causative agent is Clostridium perfringens.
Summary:
A: Clostridium perfringens is correct due to its characteristic features and association with wound infections.
B: Bacillus anthracis does not typically form terminal spores.
C: Clostridium tetani causes tetanus, not wound infections.
D: Bacillus cereus does not produce terminal spores like Clostridium perfringens.
For the structure of rubella virus, it is true that
- A. has icosahedral type of symmetry
- B. is ssDNA virus
- C. does not have an envelope
- D. does not have glycoprotein spikes
Correct Answer: A
Rationale: Step 1: Rubella virus belongs to the Togaviridae family, which typically exhibits icosahedral symmetry.
Step 2: Icosahedral symmetry refers to a structure with 20 equilateral triangular faces, which is characteristic of many viruses, including rubella.
Step 3: Therefore, choice A is correct as rubella virus indeed has icosahedral type of symmetry.
Summary:
- Choice B is incorrect as rubella virus is an ssRNA virus, not ssDNA.
- Choice C is incorrect as rubella virus does have an envelope derived from the host cell membrane.
- Choice D is incorrect as rubella virus does have glycoprotein spikes on its surface.
Which bacterium is known for producing an exotoxin that causes severe diarrhea?
- A. Clostridium tetani
- B. Clostridium botulinum
- C. Vibrio cholerae
- D. Shigella dysenteriae
Correct Answer: C
Rationale: Rationale:
1. Vibrio cholerae produces cholera toxin causing severe diarrhea.
2. Clostridium tetani causes tetanus, not diarrhea.
3. Clostridium botulinum causes botulism, not diarrhea.
4. Shigella dysenteriae causes dysentery, not typical diarrhea.
Summary:
A: Incorrect, causes tetanus.
B: Incorrect, causes botulism.
C: Correct, produces cholera toxin causing severe diarrhea.
D: Incorrect, causes dysentery.