Nokea
Drugs that may interact with vaccines include:
- A. Immunosuppressants
- B. Antibiotics
- C. Antihistamines
- D. All of the above
Correct Answer: A
Rationale: Choice A is correct because immunosuppressants (e.g., prednisone) reduce vaccine efficacy by weakening immune response, per CDC guidelines. Choice B is incorrect as antibiotics don't typically affect vaccines. Choice C is wrong because antihistamines lack vaccine interactions. Choice D is incorrect since only immunosuppressants apply.
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Drugs that are Pregnancy Category C:
- A. Have known fetal risks that outweigh the benefits
- B. Have no adequate studies in pregnant women
- C. Are proven safe in pregnancy
- D. All of the above
Correct Answer: B
Rationale: Choice B is correct because Category C drugs lack sufficient human studies, with animal studies showing risk or no data, used only if benefits justify, per FDA. Choice A is incorrect as that defines Category X, not C. Choice C is wrong because Category B, not C, indicates safety. Choice D is incorrect since only B fits Category C.
Drugs that require refrigeration include:
- A. Insulin
- B. Amoxicillin suspension
- C. Vaccines
- D. All of the above
Correct Answer: D
Rationale: Choice D is correct because insulin (protein stability), amoxicillin suspension (post-reconstitution), and vaccines (biological potency) require refrigeration to maintain efficacy, per storage guidelines. Choice A is incorrect alone as it's one drug. Choice B is wrong by itself because amoxicillin is just part. Choice C is incorrect solo since vaccines are only one group.
Drugs that may cause sedation in the elderly include:
- A. Benzodiazepines
- B. Antihistamines
- C. Opioids
- D. All of the above
Correct Answer: D
Rationale: Choice D is correct because benzodiazepines (e.g., lorazepam), antihistamines (e.g., diphenhydramine), and opioids (e.g., oxycodone) all cause sedation, increasing fall risk in the elderly, per Beers Criteria. Choice A is incorrect alone as it's one class. Choice B is wrong by itself because antihistamines are just part. Choice C is incorrect solo since opioids are only one group.
Resources for patients with drug abuse issues include:
- A. Substance Abuse and Mental Health Services Administration (SAMHSA)
- B. National Institute on Drug Abuse (NIDA)
- C. Local support groups
- D. All of the above
Correct Answer: D
Rationale: Choice D is correct because SAMHSA (helpline), NIDA (research/support), and local groups (e.g., AA) provide comprehensive resources for drug abuse, per national frameworks. Choice A is incorrect alone as it's one resource. Choice B is wrong by itself because NIDA is just part. Choice C is incorrect solo since groups are only one option.
Drugs that are affected by genetic polymorphisms of UGT1A1 include:
- A. Warfarin
- B. Irinotecan
- C. Acetaminophen
- D. All of the above
Correct Answer: B
Rationale: Choice B is correct because irinotecan's active metabolite is glucuronidated by UGT1A1; poor function increases toxicity, requiring genetic consideration. Choice A is incorrect as warfarin's metabolism is via CYP2C9, not UGT1A1. Choice C is wrong because acetaminophen uses other UGT enzymes, not specifically UGT1A1 critically. Choice D is incorrect since only irinotecan is notably affected by UGT1A1 polymorphisms.