Nokea
Fasting for an extended period can:
- A. Increase drug absorption due to lack of competition between food and the drug
- B. Alter the pH of the gastrointestinal tract, affecting absorption
- C. Cause vasoconstriction, leading to decreased drug absorption
- D. Shrink the stomach, causing decreased surface area for drug absorption
Correct Answer: A
Rationale: Fasting increases absorption of some drugs by eliminating food-related delays in gastric emptying and competition for absorption.
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Metformin is a primary choice of drug to treat hyperglycemia in type 2 diabetes because it:
- A. Substitutes for insulin usually secreted by the pancreas
- B. Decreases glycogenolysis by the liver
- C. Increases the release of insulin from beta cells
- D. Decreases peripheral glucose utilization
Correct Answer: B
Rationale: Metformin reduces hepatic glucose output (glycogenolysis), key in type 2 diabetes; it doesn't mimic insulin or increase release .
Which of the following is the indication for glucocorticoid prescribing?
- A. Cataract
- B. Prevention of respiratory distress
- C. Hypofunction of thyroid gland
- D. Hypocalcemia
Correct Answer: B
Rationale: Glucocorticoids prevent respiratory distress, such as in neonatal respiratory distress syndrome.
In the blood glucocorticoids cause:
- A. Increase amount of eosinophles
- B. Lymphocytosis
- C. Increase amount of neutrophils
- D. Increase amount of basophiles
Correct Answer: C
Rationale: Glucocorticoids increase neutrophils while decreasing eosinophils and lymphocytes in the blood.
A 43-year-old woman with Type-2 diabetes has been taking insulin with meals as well as metformin. Her blood glucose remains poorly controlled. Her doctor prescribes an additional drug, which is an analog of an endogenous peptide that enhances insulin secretion. What drug is this?
- A. Exenatide
- B. Glipizide
- C. Miglitol
- D. Pramlintide
Correct Answer: A
Rationale: Exenatide, a GLP-1 analog, enhances insulin secretion in a glucose-dependent manner, aiding type 2 diabetes control.
Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to prescribing warfarin.
- A. TRUE
- B. FALSE
Correct Answer: B
Rationale: VCORC1 testing is recommended but not required before prescribing warfarin; it's optional to guide dosing.