Four clients are receiving tyrosine kinase inhibitors (TKIs). Which of these four clients should the nurse assess first?
Correct Answer: C
Rationale: Tyrosine kinase inhibitors (TKIs) target cancer cell signaling pathways but can cause electrolyte imbalances, among other side effects. A serum potassium of 2.8 mEq/L (normal 3.5-5.0 mEq/L) is critically low, risking cardiac arrhythmias or muscle dysfunction, making this client the priority for immediate assessment. Dry, itchy, peeling skin is a common TKI side effect, uncomfortable but not immediately life-threatening, warranting later attention for infection risk. A calcium level of 9.2 mg/dL is normal (8.5-10.2 mg/dL), requiring no urgent action. A 0.5-pound weight gain in a day is minor and less critical unless part of a pattern suggesting fluid retention. The nurse prioritizes the potassium imbalance due to its potential for rapid, severe consequences, reflecting oncology's emphasis on addressing physiological instability first.