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Gram-negative rods producing blue-green pigment and a fruity odor were isolated from a wound infection. What is the causative agent?
- A. Pseudomonas aeruginosa
- B. Proteus mirabilis
- C. Klebsiella pneumoniae
- D. Escherichia coli
Correct Answer: A
Rationale: The correct answer is A: Pseudomonas aeruginosa. P. aeruginosa is known for producing a blue-green pigment called pyocyanin, which gives a characteristic color to the colonies. The fruity odor is due to the production of a compound called 2-aminoacetophenone by P. aeruginosa. These features are classic for P. aeruginosa and help differentiate it from other Gram-negative rods. Proteus mirabilis (B) typically does not produce blue-green pigment or fruity odor. Klebsiella pneumoniae (C) and Escherichia coli (D) also do not exhibit these specific characteristics associated with P. aeruginosa.
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Which statement for immunomodulators is correct
- A. they can only stimulate the incomplete humoral and immune response
- B. Isoniazid is a very effective immunomodulator
- C. they can be natural and artificial compounds
- D. they can only suppress the incomplete humoral and immune response
Correct Answer: C
Rationale: Rationale:
Choice C is correct because immunomodulators can indeed be natural (e.g., cytokines) or artificial compounds (e.g., synthetic peptides). They work by modulating the immune response, enhancing or suppressing it as needed.
Choice A is incorrect because immunomodulators can stimulate both humoral and cellular immune responses.
Choice B is incorrect as isoniazid is primarily an antibiotic used to treat tuberculosis, not an immunomodulator.
Choice D is incorrect because immunomodulators can have varying effects on the immune response, not just suppress it.
The bacteria that produces a thick pseudomembrane in the throat is:
- A. Corynebacterium diphtheriae
- B. Streptococcus pyogenes
- C. Neisseria meningitidis
- D. Bacillus cereus
Correct Answer: A
Rationale: Rationale:
1. Corynebacterium diphtheriae is the correct answer as it is the bacteria responsible for causing diphtheria, characterized by a thick pseudomembrane in the throat.
2. Streptococcus pyogenes causes strep throat but does not produce a pseudomembrane.
3. Neisseria meningitidis causes meningitis and septicemia, not a throat pseudomembrane.
4. Bacillus cereus causes food poisoning, not throat-related symptoms.
Which scientist performed the first successful vaccination against smallpox?
- A. Pasteur
- B. Jenner
- C. Semmelweis
- D. Koch
Correct Answer: B
Rationale: The correct answer is B: Jenner. Edward Jenner is credited with performing the first successful vaccination against smallpox in 1796. He used cowpox virus to inoculate individuals, leading to immunity against smallpox. Jenner's experiment laid the foundation for modern vaccination. Pasteur (A) is known for developing the germ theory of disease. Semmelweis (C) advocated for handwashing to prevent infections. Koch (D) identified the causative agents of several diseases but did not develop the smallpox vaccine.
Patients planned for treatment with monoclonal antibodies are tested for:
- A. HBV
- B. HCV
- C. M. tuberculosis
- D. All are correct
Correct Answer: D
Rationale: The correct answer is D: All are correct. Patients planned for treatment with monoclonal antibodies should be tested for HBV, HCV, and M. tuberculosis due to the risk of reactivation of these infections during treatment. HBV and HCV reactivation can lead to severe liver damage, while M. tuberculosis reactivation can cause serious respiratory complications. Testing for all three infections helps in identifying and managing any pre-existing infections to ensure patient safety during monoclonal antibody treatment. Choices A, B, and C are incorrect because each of these infections presents specific risks that need to be assessed before initiating monoclonal antibody therapy.
After consumption some tinned meat a patient had diplopia, acute headache, deglutition disorder, hard breathing, muscle weakness. The diagnosis was botulism. What factor of pathogenicity are the clinic presentations of this disease connected with?
- A. Exotoxin B.Hemolysin C.Endotoxin D.Plasmocoagulase E.Fibrinolysin
Correct Answer: A
Rationale: The correct answer is A, Exotoxin. Botulism is caused by the exotoxin produced by Clostridium botulinum bacteria. The symptoms described - diplopia, acute headache, deglutition disorder, hard breathing, muscle weakness - are all consistent with botulism due to the neurotoxic effects of the exotoxin. The exotoxin interferes with neurotransmission at the neuromuscular junction, leading to muscle paralysis and the symptoms mentioned. The other choices (B, C, D, E) are incorrect as they do not correspond to the pathogenic mechanism of botulism and do not explain the specific clinical manifestations observed in this case.