Nokea
Hepatitis B immune globulin is administered to provide passive immunity to:
- A. Infants born to HBsAg-positive mothers
- B. Household contacts of hepatitis-B virus infected people
- C. Persons exposed to blood containing hepatitis B virus
- D. All of the above
Correct Answer: D
Rationale: Hepatitis B immune globulin provides passive immunity in all listed exposure scenarios .
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When reviewing the phases of drug development, the nurse finds a discussion about the postmarketing surveillance phase. Which one of the following activities would the nurse expect to find as being carried out during this phase?
- A. Health care providers report adverse effects to FDA.
- B. Healthy volunteers are involved in the test.
- C. In vitro tests are performed using human cells.
- D. The drug is given to patients with the disease.
Correct Answer: A
Rationale: The postmarketing surveillance phase of drug development encourages health care professionals to report adverse effects of drugs to the FDA using MedWatch. Phase 1 of clinical testing involves 20 to 100 healthy volunteers. In vitro testing of the drug on human or animal cells is done in the pre-FDA phase. In Phase 2 of clinical testing, the drug is given to patients with the disease for which the drug is manufactured.
Rabi is being prescribed phenytoin for seizures. Monitoring includes assessing:
- A. For phenytoin hypersensitivity syndrome 3 to 8 weeks after starting treatment
- B. For pedal edema throughout therapy
- C. Heart rate at each visit and consider altering therapy if heart rate is less than 60 bpm
- D. For vision changes, such as red-green blindness, at least annually
Correct Answer: A
Rationale: Phenytoin hypersensitivity syndrome can occur 3-8 weeks post-initiation.
You are evaluating the discharge teaching you have done with your patient concerning their drug therapy. What statement from the patient would indicate that teaching had been effective?
- A. I have to take three pills each day. It doesn't matter when.'
- B. I should take the white pill in the morning and the green pill in the afternoon. I don't know what they are called.'
- C. I need to tell all my other doctors that I am taking this Coumadin because it could interact with other drugs.'
- D. I think I could cut that pill in half if I wanted to.'
Correct Answer: C
Rationale: Understanding drug interactions with Coumadin (warfarin) shows effective teaching on safety and coordination of care.
All the following induce hepatic enzymes except
- A. Rifampicin
- B. Phenytoin
- C. Barbiturates
- D. Tolbutamide
Correct Answer: D
Rationale: Tolbutamide does not significantly induce enzymes; others do.
The nurse, providing patient teaching about home medication use to an older adult, explains that even when drugs are taken properly they can produce negative or unexpected effects. What are these negative or unexpected effects called?
- A. Teratogenic effects
- B. Toxic effects
- C. Adverse effects
- D. Therapeutic effects
Correct Answer: C
Rationale: Negative or unexpected effects are known as adverse or side effects. Teratogenic effects are adverse effects on the fetus and not a likely concern for an older adult. Toxic effects occur when medication is taken in larger than recommended dosages caused by an increase in serum drug levels. Therapeutic effects are the desired actions for which the medication is prescribed.