TEAS 7 science practice questions Related

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How do spindle fiber dynamics and microtubule attachment regulate cell cycle checkpoints?

  • A. Misaligned chromosomes fail to attach to microtubules, triggering a delay in anaphase onset.
  • B. The presence of unattached kinetochores on the centromeres sends a signal to pause cell cycle progression.
  • C. Microtubule instability and rapid depolymerization lead to the activation of checkpoint proteins.
  • D. All of the above.
Correct Answer: D

Rationale: A) Misaligned chromosomes fail to attach to microtubules, triggering a delay in anaphase onset: Proper attachment of chromosomes to spindle fibers is essential for accurate segregation of genetic material during cell division. Misaligned chromosomes that fail to attach to microtubules can lead to delays in anaphase onset, allowing the cell to correct errors before proceeding with division.

B) The presence of unattached kinetochores on the centromeres sends a signal to pause cell cycle progression: Kinetochores at the centromeres help attach chromosomes to spindle fibers. When kinetochores are unattached or improperly attached to microtubules, they signal the cell to pause cell cycle progression, ensuring proper chromosome alignment before division.

C) Microtubule instability and rapid depolymerization lead to the activation of checkpoint proteins: While microtubule dynamics are crucial for cell division, microtubule instability and rapid depolymerization can disrupt chromosome attachment. However, this mechanism is not directly related to the activation of cell cycle checkpoint proteins, making this statement incorrect.

Therefore, choices A and B accurately describe how spindle fiber dynamics and microtubule attachment regulate cell cycle checkpoints, making option D the correct answer.