Nokea
Identify potential drug-drug interactions that may occur with tamoxifen
- A. Not provided in document
- B. Not provided in document
- C. Not provided in document
- D. Not provided in document
Correct Answer: D
Rationale: This question lacks options in the document, but based on the answer key (ANS: 4), it is assumed to correspond to the fourth choice if options were present. Tamoxifen has significant interactions with CYP2D6 inhibitors (e.g., SSRIs), which can reduce its efficacy.
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Candesartan and irbesartan are angiotensin receptor blockers that are used to treat hypertension. The therapeutic dose range for candesartan is 4 to 32 mg, as compared to 75 to 300 mg for irbesartan. which of the following regarding this statement is correct?
- A. Candesartan is more potent than is irbesartan
- B. Candesartan and irbesartan have different efficacy
- C. Candesartan is a non competitive antagonist for irbesartan
- D. Irbesartan is a competitive antagonist for candesartan
Correct Answer: A
Rationale: Lower dose range for candesartan indicates higher potency (lower EC50) compared to irbesartan.
The following can be used for diabetes mellitus:
- A. Desmoporesine
- B. Insuline preparations
- C. Chlorpropamide
- D. Metformin
Correct Answer: A
Rationale: Insulin, chlorpropamide, metformin, and acarbose (B, C, D, E) are all used for diabetes management.
True contraindications to diphtheria, tetanus, and acellular pertussis (DTaP or Tdap) vaccine include:
- A. Fever up to 104°F (40.5°C) after previous DTaP vaccine
- B. Family history of seizures after DTaP vaccine
- C. Adolescent pregnancy
- D. Anaphylactic reaction with a previous dose
Correct Answer: D
Rationale: Anaphylaxis is a true contraindication to DTaP/Tdap; fever , family history , or pregnancy are not.
A nurse is providing teaching for a client who is withdrawing from alcohol and has a new prescription for Propranolol. Which of the following information should the nurse to include in the teaching?
- A. Increases the risk for seizure activity
- B. Provides a form of aversion therapy
- C. Decreases cravings
- D. Results in mild hypertension
Correct Answer: C
Rationale: Propranolol reduces withdrawal symptoms like tremors and cravings , not seizures or aversion.
When given subcutaneously, how long until neutral protamine Hagedorn insulin begins to take effect (onset of action) after administration?
- A. 15 to 30 minutes
- B. 60 to 90 minutes
- C. 3 to 4 hours
- D. 6 to 8 hours
Correct Answer: B
Rationale: NPH insulin has an onset of 60-90 minutes; shorter is rapid-acting, longer is basal.