Nokea
Immunosuppressive drugs are not used for:
- A. Organ transplantation
- B. Measles
- C. Autoimmune diseases
- D. Hemolytic disease of the newborn
Correct Answer: B
Rationale: The correct answer is B: Measles. Immunosuppressive drugs are not used for treating viral infections like measles as they target the immune system and can worsen the infection. Organ transplantation requires immunosuppressive drugs to prevent organ rejection. Autoimmune diseases involve an overactive immune response, so immunosuppressive drugs are used to reduce this response. Hemolytic disease of the newborn can be treated with immunosuppressive drugs to prevent the destruction of red blood cells.
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A family has two children. The younger child is under the year. The child has developed spastic cough attacks. Similar clinical presentation was observed in the elder preschool child one month ago. The doctor suspects pertussis infection. What method enables retrospective diagnostics of this disease?
- A. Serological
- B. Biological
- C. Bacteriological
- D. Molecular biological
Correct Answer: A
Rationale: The correct answer is A: Serological. Serological testing involves analyzing blood samples for specific antibodies produced in response to the pertussis infection. This method can detect past infections by identifying the presence of antibodies against the pertussis bacteria in the blood. In this case, since the doctor suspects pertussis infection in both children, serological testing can confirm if they have been exposed to the bacteria.
Summary:
B: Biological testing does not specifically target pertussis antibodies in the blood.
C: Bacteriological testing involves culturing bacteria from samples, which may not be as sensitive for retrospective diagnosis.
D: Molecular biological testing focuses on genetic material of the bacteria, which may not provide direct evidence of past infection.
A patient with diarrhea had fecal analysis revealing small, curved Gram-negative bacilli with a monotrichous flagellum. These bacteria do not form spores or capsules and thrive in alkaline conditions. What is the causative agent?
- A. Vibrio cholerae
- B. Escherichia coli
- C. Salmonella
- D. Shigella
Correct Answer: A
Rationale: Step 1: Small, curved Gram-negative bacilli with a monotrichous flagellum point towards a motile bacterium.
Step 2: The absence of spores or capsules and preference for alkaline conditions further narrows down the possibilities.
Step 3: Vibrio cholerae fits all criteria as it is a curved, motile, Gram-negative bacillus that thrives in alkaline environments.
Summary: Escherichia coli is a facultative anaerobe, Salmonella and Shigella are non-flagellated, and all of them can form capsules or spores, unlike Vibrio cholerae.
Sanitary and bacteriological examination of air in drug-store premises revealed increased content of sanitary representative microorganisms. What microorganisms are these?
- A. Golden staphylococcus and hemolytic streptococcus
- B. Diphtheria and tuberculosis bacilli
- C. Colon and blue pus bacilli
- D. Epidermal staphylococcus and sarcina
Correct Answer: A
Rationale: The correct answer is A (Golden staphylococcus and hemolytic streptococcus) because these microorganisms are commonly found in the air of contaminated environments like drug-store premises. Golden staphylococcus and hemolytic streptococcus are pathogenic bacteria associated with infections in humans, indicating poor sanitation. The other choices are incorrect because:
B: Diphtheria and tuberculosis bacilli are not commonly found in the air in drug-store premises.
C: Colon and blue pus bacilli are not typical microorganisms associated with air contamination.
D: Epidermal staphylococcus and sarcina are not likely to be present in high amounts in the air of drug-store premises.
The term used to indicate the extent to which a drug reaches its site of action is:
- A. bioactivity
- B. bioavailability
- C. bioremediation
- D. biostasis
Correct Answer: B
Rationale: The correct answer is B: bioavailability. Bioavailability refers to the extent and rate at which a drug reaches its site of action in the body. This includes factors such as absorption, distribution, metabolism, and excretion.
Rationale:
1. Bioactivity refers to the pharmacological effect of a drug, not how effectively it reaches its site of action.
2. Bioremediation is the process of using organisms to remove or neutralize pollutants, not related to drug delivery.
3. Biostasis refers to a state of equilibrium or balance in living organisms, not related to drug transport to its site of action.
In summary, bioavailability is the most appropriate term as it specifically addresses the process of a drug reaching its intended target within the body, distinguishing it from the other choices.
On the base of the clinical data a child was diagnosed with atypical pneumonia resistant to the effects of beta-lactam antibiotics. The patient's sputum was cultured and incubated in a special medium, which resulted in growth of microorganisms forming microscopic colonies with a dense center (looking like fried eggs). What microorganism caused the disease?
- A. Mycoplasma pneumoniae
- B. Klebsiella pneumoniae
- C. Str. pneumoniae
- D. L. pneumophila
Correct Answer: A
Rationale: The correct answer is A: Mycoplasma pneumoniae. Mycoplasma pneumoniae is a common cause of atypical pneumonia and is known to be resistant to beta-lactam antibiotics. The description of microorganisms forming microscopic colonies with a dense center resembling fried eggs is characteristic of Mycoplasma pneumoniae colonies seen on special media.
Summary of other choices:
B: Klebsiella pneumoniae is not typically associated with atypical pneumonia and does not exhibit the described colony morphology.
C: Streptococcus pneumoniae is not resistant to beta-lactam antibiotics and does not produce colonies with the described appearance.
D: Legionella pneumophila is associated with Legionnaires' disease, not atypical pneumonia, and does not form colonies resembling fried eggs.