Nokea
Indicate the incorrect statement. Chronic granulomatous disease is
- A. Caused by defective recruitment of neutrophils to sites of infection
- B. Associated with defective respiratory burst of neutrophils
- C. Caused by mutations of the NADPH oxidase genes
- D. Associated with recurrent bacterial infections
Correct Answer: A
Rationale: The correct answer is A. Chronic granulomatous disease (CGD) is caused by mutations of the NADPH oxidase genes, leading to defective respiratory burst in neutrophils. Neutrophils are recruited to sites of infection normally in CGD. Therefore, choice A is incorrect. Choices B, C, and D are incorrect because CGD is indeed associated with defective respiratory burst of neutrophils due to mutations in NADPH oxidase genes, leading to recurrent bacterial infections.
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An HIV encoded protein that if targeted therapeutically could result in the blocking of binding of HIV to T lymphocytes is
- A. Reverse transcriptase (RT)
- B. Viral proteases
- C. gp41
- D. Matrix protein
Correct Answer: E
Rationale: It seems like there might be a mistake with the question as the correct answer is not provided. If you could provide the correct answer, I would be happy to provide a detailed explanation for it.
How do NK cells kill target cells?
- A. By producing antibodies
- B. Through secretion of cytokines
- C. By releasing perforin and granzyme
- D. By phagocytosis
Correct Answer: C
Rationale: The correct answer is C. NK cells kill target cells by releasing perforin and granzyme. Perforin creates pores in the target cell's membrane, allowing granzyme to enter and induce apoptosis. Antibodies (choice A) are produced by B cells, not NK cells. Cytokines (choice B) regulate immune responses but do not directly kill cells. Phagocytosis (choice D) involves engulfing and digesting pathogens, which is not how NK cells kill target cells.
Your patient with rheumatoid arthritis (RA) is taking prednisone (Deltasone) and naproxen (Alleve) to reduce inflammation and joint pain. Which of these symptoms is the strongest indicator that a change in therapy may be necessary?
- A. The patient states that the RA symptoms are worst in the morning.
- B. The patient complains about having dry eyes.
- C. The patient has round and moveable nodules just under the skin.
- D. The patient has stools that are very dark in color.
Correct Answer: D
Rationale: Dark stools can indicate gastrointestinal bleeding which is a serious side effect of NSAIDs like naproxen. This requires immediate attention and possibly a change in therapy. The other symptoms while related to RA do not indicate an urgent need for a change in treatment.
A patient is scheduled to have a tunneled catheter placed for administration of chemotherapy for breast cancer. When preparing the patient for the catheter insertion, what does the nurse explain about this method of chemotherapy administration?
- A. Decreases the risk for extravasation at the infusion site
- B. Reduces the incidence of systemic side effects of the drug
- C. Does not become occluded as peripherally inserted catheters can
- D. Allows continuous infusion of the drug directly to the area of the tumor
Correct Answer: A
Rationale: Tunneled catheters reduce extravasation risks compared to peripheral lines by delivering medications centrally.
Monoclonal antibodies can be used to:
- A. Block the proliferation of cancer cells
- B. Target cancer cells for destruction
- C. Inhibit inflammatory immune responses
- D. All of the above
Correct Answer: D
Rationale: The correct answer is D because monoclonal antibodies have the ability to block the proliferation of cancer cells by targeting specific antigens on the cancer cells. They can also target cancer cells for destruction through various mechanisms such as antibody-dependent cell-mediated cytotoxicity. Additionally, monoclonal antibodies can inhibit inflammatory immune responses by neutralizing pro-inflammatory mediators or blocking immune cell activation pathways. Therefore, all the options A, B, and C are correct, making D the correct answer.