Nokea
List FOUR differential diagnoses aside from aortic coarctation for a two-week old infant presenting with tachypnea and poor femoral pulses.
- A. Tachycardia induced cardiomyopathy
- B. Critical aortic stenosis
- C. Dilated cardiomyopathy
- D. Myocarditis
Correct Answer: A
Rationale: Differential diagnoses in such cases can include non-structural heart conditions like tachycardia induced cardiomyopathy, which affects the heart's ability to pump effectively.
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Epiphyseal changes are seen in:
- A. Non-accidental injury
- B. Rickets
- C. Chronic renal failure
- D. Lead poisoning
Correct Answer: B
Rationale: Rickets is characterized by epiphyseal changes due to defective mineralization of growing bones.
The following are transmitted as autosomal dominant traits:
- A. Congenital spherocytosis
- B. Vitamin D-resistant rickets
- C. CAH
- D. Hereditary haemorrhagic telangiectasia
Correct Answer: D
Rationale: Hereditary haemorrhagic telangiectasia is an autosomal dominant disorder. Congenital spherocytosis and Vitamin D-resistant rickets can also be autosomal dominant, but CAH (Congenital Adrenal Hyperplasia) is typically autosomal recessive.
In normal neonates:
- A. Extracellular fluid volume exceeds intracellular fluid volume
- B. In a term baby, plasma calcium levels exceed that of the mother
- C. Clamping the umbilical cord after cessation of cord pulsations increases the blood volume by 20% in the baby
- D. There are two arteries and one vein in the umbilical cord
Correct Answer: A
Rationale: In neonates, extracellular fluid volume is greater than intracellular fluid volume, reflecting the transition from intrauterine to extrauterine life.
All of the following are true about a small VSD EXCEPT
- A. spontaneous closure is more common in muscular vs. membranous defects
- B. closure usually occurs in the first 2 years of life
- C. there is no risk of endocarditis
- D. pulmonary pressures are normal
Correct Answer: C
Rationale: Even small VSDs carry a risk of endocarditis until they close.
Inclisiran used in the treatment of dyslipidemia is chemically a
- A. Synthetic RNA
- B. Synthetic histone
- C. Synthetic DNA
- D. Synthetic mitochondria
Correct Answer: A
Rationale: Inclisiran is a synthetic RNA molecule used to lower cholesterol levels.