Nokea
Methylnaltrexone is used to treat constipation in:
- A. Patients with functional constipation
- B. Patients with irritable bowel syndrome-associated constipation
- C. Children with encopresis
- D. Opioid-associated constipation
Correct Answer: D
Rationale: Methylnaltrexone specifically reverses opioid-induced constipation; it's not for functional , IBS , or pediatric use.
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A patient who has a long history of alcohol abuse is admitted to the hospital for detoxification. In addition to medications needed to treat withdrawal symptoms, the nurse will anticipate giving intravenous
- A. dopamine to restore blood pressure
- B. fluid boluses to treat dehydration
- C. glucose to prevent hypoglycemia
- D. thiamine to treat nutritional deficiency
Correct Answer: D
Rationale: Thiamine prevents Wernicke's encephalopathy in alcohol detox; glucose follows if needed. Thiamine should be given to prevent Wernicke's encephalopathy in patients treated for alcoholism.
The primary use of aminoglycosides is to treat:
- A. Gram-positive infections
- B. Gram-negative infections
- C. Fungal infections
- D. Viral infections
Correct Answer: B
Rationale: Aminoglycosides like gentamicin are primarily effective against Gram-negative bacteria due to their mechanism targeting bacterial ribosomes.
An disorder develops lactic acidosis, and nearly dies, as a result of an uncommon but serious adverse response to therapy with an 'endocrine' drug. Which of the following was the most likely cause of this severe problem?
- A. Insulin glargine, prescribed for Type 1 diabetes mellitus
- B. Levothyroxine, prescribed to maintain euthyroid status following thyroidectomy
- C. Metformin, prescribed for Type 2 diabetes mellitus
- D. Propylthiouracil, prescribed for hyperthyroidism
Correct Answer: C
Rationale: Metformin is the most likely cause of lactic acidosis, a rare but life-threatening complication.
Which of the following antidiabetic agents acts on the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) nuclear receptor?
- A. acarbose
- B. glyburide
- C. insulin lispro
- D. pioglitazone
Correct Answer: D
Rationale: Pioglitazone is a thiazolidinedione that activates PPAR-gamma, enhancing insulin sensitivity in peripheral tissues.
Vitamin B12 deficiency may lead to:
- A. Hair loss
- B. Insomnia
- C. Dry scales on the scalp
- D. Numbness and tingling of the hands
Correct Answer: D
Rationale: Vitamin B12 deficiency causes neurological symptoms like numbness and tingling due to nerve damage.