Chronic Illness NCLEX Questions Related

Review Chronic Illness NCLEX Questions related questions and content

Mr Yee two months later. At your last visit he did not want colchicine prophylaxis as he did not want to take 'too many tablets'. He has started and is adherent to his urate lowering agent. Last month, his uric acid had decreased to 390 mmol/L. He had a gout flare last week, hence he came to your clinic today to ask about colchicine prophylaxis. Which is correct advice regarding colchicine prophylaxis?

  • A. Offer to start colchicine at 500 mcg once daily or alternate days as gout prophylaxis as his renal function is abnormal
  • B. Colchicine cannot help to reduce the frequency of flares especially during the first six months of Urate lowering therapy
  • C. Tell him that if he is started on clarithromycin, he does not need to inform his doctor or pharmacist that he is on colchicine regularly as colchicine can have drug interactions
  • D. Regular colchicine prophylaxis in someone with normal renal function and regular monitoring can lead to renal failure
Correct Answer: A

Rationale: With eGFR 55 mL/min and a recent flare despite uric acid dropping to 390 mmol/L, colchicine prophylaxis at 500 mcg daily or alternate days is appropriate, adjusting for reduced renal clearance to prevent toxicity. Flares are common early in ULT as urate mobilizes, and colchicine reduces this, contrary to the false claim it can't help. Clarithromycin interacts dangerously with colchicine (CYP3A4 inhibition), requiring disclosure. Colchicine doesn't cause renal failure with monitoring; toxicity does. This dose suits chronic gout management safely.