HESI Pharmacology Practice Exam Related

Review HESI Pharmacology Practice Exam related questions and content

Nalidixic acid (NegGram) is prescribed for a client with a urinary tract infection. On review of the client's record, the nurse notes that the client is taking warfarin sodium (Coumadin) daily. Which prescription should the nurse anticipate for this client?

  • A. Discontinuation of warfarin sodium (Coumadin)
  • B. A decrease in the warfarin sodium (Coumadin) dosage
  • C. An increase in the warfarin sodium (Coumadin) dosage
  • D. A decrease in the usual dose of nalidixic acid (NegGram)
Correct Answer: B

Rationale: Nalidixic acid can intensify the effects of oral anticoagulants by displacing these agents from binding sites on plasma proteins. When an oral anticoagulant, like warfarin sodium (Coumadin), is combined with nalidixic acid, a decrease in the anticoagulant dosage may be necessary to avoid excessive anticoagulation and potential bleeding risks.