Nokea
One of the basic principles of chemotherapy is:
- A. Selective toxicity
- B. Accumulation in the macroorganism
- C. Causing allergies to the macroorganism
- D. None of the above
Correct Answer: A
Rationale: The correct answer is A: Selective toxicity. Chemotherapy aims to target cancer cells while minimizing harm to healthy cells, known as selective toxicity. This principle is crucial to effectively treat cancer without causing excessive damage to the patient's body. Accumulation in the macroorganism (B) and causing allergies (C) are not fundamental principles of chemotherapy and can lead to harmful side effects. Therefore, the correct answer is A as it aligns with the core objective of chemotherapy.
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Flagellin is:
- A. A protein
- B. A carbohydrate
- C. A staining method
- D. An organelle
Correct Answer: A
Rationale: Flagellin is a protein component of bacterial flagella. It is not a carbohydrate, staining method, or an organelle. The correct answer is A because flagellin is a structural protein that forms the flagellar filament. It helps in bacterial motility and pathogenicity. Therefore, the correct choice is A.
A bacteriological laboratory received sputum sample of a patient suffering from tuberculosis. Bacterioscopic examination of smears and detection of tuberculosis bacillus can be realized by one of enrichment methods that involves processing of sputum only with solution of caustic soda. What is this method called?
- A. Homogenization
- B. Inactivation
- C. Flotation
- D. Filtration
Correct Answer: B
Rationale: The correct answer is B: Inactivation. In this method, the sputum sample is processed with a solution of caustic soda, which helps to kill any contaminants present and preserve the tuberculosis bacillus for microscopic examination. This step is crucial in ensuring accurate detection of the bacillus.
A: Homogenization involves breaking down the sample to make it uniform, but it does not necessarily involve using caustic soda for inactivation.
C: Flotation is a method used to separate different components based on their density and is not specific to inactivating tuberculosis bacillus.
D: Filtration involves passing a sample through a filter to separate particles based on size and is not related to inactivating the tuberculosis bacillus.
Which of the following bacteria are unable to synthesize ATP?
- A. Chlamydia
- B. Enterococci
- C. Rickettsia
- D. Staphylococci
Correct Answer: A
Rationale: The correct answer is A: Chlamydia. Chlamydia lacks the essential enzymes for ATP synthesis and relies on host cell ATP. Enterococci, Rickettsia, and Staphylococci possess the necessary enzymes for ATP synthesis through cellular respiration. Chlamydia's inability to synthesize ATP makes it dependent on the host cell for energy production, distinguishing it from the other bacteria listed.
By precipitation of tuberculin, a purified protein derivative (PPD) is obtained. It is used in:
- A. Mantoux test
- B. Schick test
- C. Dick test
- D. None of the above
Correct Answer: A
Rationale: The correct answer is A: Mantoux test. The Mantoux test is used to screen for tuberculosis by injecting PPD intradermally. The presence of a delayed hypersensitivity reaction indicates prior exposure to Mycobacterium tuberculosis. The Schick test (B) is used to test for immunity to diphtheria, while the Dick test (C) is used to test for immunity to scarlet fever. Therefore, the correct use of PPD is in the Mantoux test for tuberculosis screening.
Which of the following is used to test for bacterial antibiotic susceptibility?
- A. Gram stain
- B. Catalase test
- C. Kirby-Bauer disk diffusion test
- D. Endospore stain
Correct Answer: C
Rationale: The correct answer is C: Kirby-Bauer disk diffusion test. This test is used to determine the antibiotic susceptibility of bacteria by measuring the zone of inhibition around antibiotic-soaked paper disks. It helps identify which antibiotics are effective against the bacteria being tested. This test is crucial in guiding antibiotic treatment decisions.
A: Gram stain is used to classify bacteria based on their cell wall composition and morphology, not for antibiotic susceptibility testing.
B: Catalase test is used to differentiate between catalase-positive and catalase-negative bacteria, not for antibiotic susceptibility testing.
D: Endospore stain is used to detect the presence of endospores in bacteria, not for antibiotic susceptibility testing.