Nokea
Ototoxicity is more likely if aminoglycosides are administered with which of the following drug classes?
- A. Loop diuretics
- B. Metformin
- C. Vancomycin
- D. Cephalosporins
Correct Answer: A
Rationale: Loop diuretics (e.g., furosemide) enhance aminoglycoside ototoxicity by increasing inner ear damage risk.
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When involved in phase III drug evaluation studies, what responsibilities would the nurse have?
- A. Working with animals who are given experimental drugs
- B. Choosing appropriate patients to be involved in the drug study
- C. Monitoring and observing patients closely for adverse effects
- D. Conducting research to determine effectiveness of the drug
Correct Answer: C
Rationale: Phase III studies involve use of a drug in a vast clinical population in which patients are asked to record any symptoms they experience while taking the drugs. Nurses may be responsible for helping collect and analyze the information to be shared with the Food and Drug Administration (FDA) but would not conduct research independently because nurses do not prescribe medications. Use of animals in drug testing is done in the preclinical trials. Select patients who are involved in phase II studies to participate in studies where the participants have the disease the drug is intended to treat. These patients are monitored closely for drug action and adverse effects. Phase I studies involve healthy human volunteers who are usually paid for their participation. Nurses may observe for adverse effects and toxicity.
Which phenothiazine has the least extra pyramidal effect
- A. Thioridazine
- B. Chlorpromazine
- C. Triflupromazine
- D. Fluphenazine
Correct Answer: A
Rationale: Thioridazine has fewer extrapyramidal effects.
The nurse caring for a patient who has tuberculosis and who is taking isoniazid, rifampin, and streptomycin reviews the medical record and notes the patient's sputum cultures reveal resistance to streptomycin. The nurse will anticipate that the provider will take which action?
- A. Add ethambutol (Myambutol)
- B. Change the streptomycin to clarithromycin
- C. Change the streptomycin to kanamycin
- D. Order renal function tests
Correct Answer: C
Rationale: Kanamycin replaces streptomycin in phase I resistance; ethambutol is for INH resistance, and clarithromycin is phase II. The patient's current regimen is first-phase treatment. If resistance to streptomycin develops, the provider can change to kanamycin or to ciprofloxacin.
A nurse is preparing to administer a prescribed drug. Which information about the drug would be most important for the nurse to know?
- A. Normal dosage range
- B. Special precautions in administration
- C. Drug's most common adverse effects
- D. All the above
Correct Answer: D
Rationale: The nurse must have factual knowledge of each drug given, the reason for use of the drug, the drug's general action, the more common adverse reactions associated with the drug, special precautions in administration (if any), and the normal dose ranges.
Methanol causes blindness due to its
- A. Hypersensitivity reactions
- B. Conjugated products
- C. Idiosyncratic reaction
- D. Oxidative products
Correct Answer: D
Rationale: Methanol's metabolite, formic acid (oxidative product), damages the optic nerve, causing blindness.