Nokea
After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as a phase? (Select one that does not apply.)
- A. Absorption
- B. Distribution
- C. Administration
- D. Metabolism
Correct Answer: C
Rationale: The pharmacokinetic phases are absorption, distribution, metabolism, and excretion. The acronym ADME is a helpful way to remember the pharmacokinetic phases.
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Which of the following does albumin have the strongest affinity for?
- A. Anionic drugs
- B. Hydrophilic drugs
- C. Hydrophobic drugs
- D. A and C
Correct Answer: C
Rationale: Albumin has the strongest affinity for hydrophobic drugs , which bind to its hydrophobic pockets, unlike hydrophilic drugs; anionic drugs may bind but less preferentially.
A pharmaceutical lab states that a drug causes negative side effects in 3 of every 100 patients. To confirm this affirmation, another laboratory chooses 5 people at random who have consumed the drug. What is the probability that at least two experience side effects?
- A. 0.8687
- B. 0.1313
- C. 0.00847
- D. 0.0003
Correct Answer: C
Rationale: The probability of at least two experiencing side effects is P(X≥2) = 1 - [P(X=0) + P(X=1)]. Using binomial calculations: P(X=0) = 0.8687, P(X=1) = (5 choose 1) * 0.03 * 0.97^4 = 0.1342, so P(X≥2) = 1 - (0.8687 + 0.1342) = 0.00847, matching the document.
In the presence of pentazocine, a higher concentration of morphine is required to elicit pain relief. Pentazocine by it self has a smaller analgesic effect than does morphine, even at the highest dose, Which of the following is correct regarding these medications?
- A. Pentazocine is a competitive antagonist
- B. Morphine is a full agonist, and pentazocine is a partial agonist
- C. Morphine is less efficacious than is pentazocine
- D. Morphine is less potent than is pentazocine
Correct Answer: B
Rationale: Pentazocine's submaximal effect and antagonism of morphine indicate it is a partial agonist, while morphine is a full agonist.
John has clonidine, a centrally acting adrenergic blocker, prescribed for his hypertension. He should:
- A. Not miss a dose or stop taking the drug because of potential rebound hypertension
- B. Increase fiber in the diet to treat any diarrhea that may occur
- C. Reduce fluid intake to less than 2 liters per day to prevent fluid retention
- D. Avoid sitting for long periods, as this can lead to deep vein thrombosis
Correct Answer: A
Rationale: Clonidine withdrawal can cause rebound hypertension, making adherence critical.
The therapeutic goals when prescribing include(s):
- A. Curative
- B. Palliative
- C. Preventive
- D. All of the above
Correct Answer: D
Rationale: Therapeutic goals can be curative, palliative, or preventive , depending on the patient's condition and needs.