Nokea
Patients with rheumatoid arthritis typically have pain:
- A. With activity.
- B. Upon awakening.
- C. Late in the evening.
- D. All day without remission.
Correct Answer: B
Rationale: Rheumatoid arthritis often causes morning stiffness and pain upon awakening due to inflammation and lack of movement during sleep. Pain tends to improve with activity as joints warm up.
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A patient comes to the clinic and requests testing for HIV infection. Before administering testing, what is most important for the nurse to do?
- A. Ask the patient to identify all sexual partners
- B. Determine when the patient thinks exposure to HIV occurred
- C. Explain that all test results must be repeated at least twice to be valid
- D. Discuss prevention practices to prevent transmission of the HIV to others
Correct Answer: D
Rationale: Prevention education is crucial to reduce further transmission risks while awaiting test results.
What is the role of perforin released by NK cells?
- A. Activating B cells
- B. Forming pores in target cell membranes
- C. Engulfing pathogens
- D. Inducing inflammation
Correct Answer: B
Rationale: Perforin released by NK cells forms pores in target cell membranes, allowing for the entry of granzymes which induce target cell death. This process is crucial for the immune response against infected or abnormal cells. Activating B cells (A) is not the role of perforin, as B cells are primarily activated by antigens. Engulfing pathogens (C) is the role of phagocytes like macrophages, not perforin. Inducing inflammation (D) is not directly related to the function of perforin in forming pores in target cell membranes.
The nurse is caring for a patient who is experiencing an immune response involving B and T cells. Which type of immunity is the patient demonstrating?
- A. Passive immunity
- B. Humoral immunity
- C. Acquired immunity
- D. Cell-mediated immunity
Correct Answer: B
Rationale: The correct answer is B: Humoral immunity. Humoral immunity involves B cells producing antibodies to target pathogens. B cells are responsible for producing antibodies that circulate in the blood and lymph to neutralize pathogens. This type of immunity is specific to antigens and is a key component of the adaptive immune response. Passive immunity (A) is when antibodies are transferred from one individual to another, not involving B and T cells directly. Acquired immunity (C) is a broad term encompassing both humoral and cell-mediated immunity. Cell-mediated immunity (D) involves T cells directly targeting infected cells, not B cells producing antibodies.
Which of the following is not required for full activation of a naïve lymphocyte?
- A. Migration into an inflammatory site
- B. Costimulatory signalling
- C. Cytokines
- D. Recognition of specific antigen
Correct Answer: A
Rationale: The correct answer is A. Naïve lymphocytes require activation through recognition of specific antigen, costimulatory signaling, and cytokines. Migration into an inflammatory site is not a requirement for full activation. Naïve lymphocytes can be activated in secondary lymphoid organs where antigen presentation occurs. Migration to inflammatory sites occurs after activation to fight infections.
How does an antigen stimulate an immune response?
- A. It is captured, processed, and presented to a lymphocyte by a macrophage.
- B. It circulates in the blood, where it comes in contact with circulating lymphocytes.
- C. It is a foreign protein that has antigenic determinants different from those of the body.
- D. It combines with larger molecules that are capable of stimulating production of antibodies.
Correct Answer: A
Rationale: Antigens are captured, processed, and presented to lymphocytes by antigen-presenting cells like macrophages, initiating an immune response.