Nokea
Pick the true statement:
- A. Amox- Clavulanic, Clavulanic increases amox activity
- B. Sublactum is used in treatment of Leprosy
- C. Aztreonam is a metabolite of clarithromycin
- D. Cilastatin imipenam- cilastatin prevents hydrolysis of imipenam
Correct Answer: B
Rationale: Sulbactam is used in leprosy treatment; other statements are incorrect (e.g., clavulanic enhances amoxicillin, cilastatin protects imipenem).
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A patient with an edema would have an increased volume of distribution (Vd) if?
- A. The patient was taking an anionic drug
- B. The patient was taking a hydrophobic drug
- C. The patient was taking a hydrophilic drug
- D. An edema always causes an increase in Vd
Correct Answer: C
Rationale: Edema increases extracellular fluid, raising Vd for hydrophilic drugs that distribute into this compartment, not hydrophobic drugs (tissue-bound) or universally.
Which of the following is used for the treatment of primary hyperaldosteronism:
- A. Furosemide
- B. Hydrocortisone
- C. Spironolactone
- D. Dexamethasone
Correct Answer: C
Rationale: Spironolactone is an aldosterone antagonist, making it effective for treating primary hyperaldosteronism by blocking excess aldosterone effects.
A patient with a history of opioid abuse will be discharged home with buprenorphine to help prevent relapse. Which product will the nurse anticipate the provider to order?
- A. Buprenex
- B. Suboxone
- C. Subutex
- D. Vivitrol
Correct Answer: A
Rationale: Buprenex is buprenorphine with low abuse potential for maintenance; Suboxone has naloxone added. Buprenex is an agonist-antagonist opioid that can be used for detoxification and maintenance therapy because it has a low potential for abuse.
Clonidine has several off-label uses, including:
- A. Alcohol and nicotine withdrawal
- B. Post-herpetic neuralgia
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: C
Rationale: Clonidine is used off-label for both alcohol/nicotine withdrawal and post-herpetic neuralgia.
A nurse is caring for a client who received IV Verapamil to treat supraventricular tachycardia (SVT). The client's pulse rate is now 98/min and his blood pressure is 74/44 mg hg. The nurse should anticipate a prescription for which of the following IV medications?
- A. Calcium gluconate
- B. Sodium bicarbonate
- C. Potassium chloride
- D. Magnesium sulfate
Correct Answer: A
Rationale: Calcium gluconate reverses verapamil-induced hypotension by counteracting calcium channel blockade.