Nokea
Priority Decision: What is the most important nursing intervention for the prevention and treatment of pressure ulcers?
- A. Using pressure-reduction devices
- B. Massaging pressure areas with lotion
- C. Repositioning the patient a minimum of every 2 hours
- D. Using lift sheets and trapeze bars to facilitate patient movement
Correct Answer: C
Rationale: Regular repositioning prevents prolonged pressure on vulnerable areas, reducing the risk of tissue ischemia and necrosis.
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Which of the following is not usually observed in severe Covid-19 cases?
- A. Prompt and sustained production of type I Interferon
- B. Autoantibodies
- C. A delayed CD4 T cell response
- D. Elevated levels of inflammatory cytokines
Correct Answer: A
Rationale: Step-by-step rationale:
1. In severe Covid-19 cases, there is usually a dysregulated immune response.
2. Type I Interferon plays a crucial role in early antiviral defense.
3. However, in severe cases, there is often a blunted or delayed response of type I Interferon.
4. This delayed response contributes to viral persistence and hyperinflammation.
5. Therefore, the prompt and sustained production of type I Interferon is not usually observed in severe Covid-19 cases.
Summary:
- Choice A is correct as the prompt and sustained production of type I Interferon is not typically observed in severe Covid-19 cases.
- Choices B, C, and D are incorrect as autoantibodies, a delayed CD4 T cell response, and elevated levels of inflammatory cytokines are commonly observed in severe Covid-19 cases.
What is the normal range for the hematocrit value in a healthy adult?
- A. 20-40%
- B. 40-60%
- C. 60-80%
- D. 80-100%
Correct Answer: B
Rationale: The correct answer is B: 40-60%. Hematocrit represents the percentage of red blood cells in the blood. The normal range for hematocrit in a healthy adult is typically around 40-60%. Values below 40% may indicate anemia, while values above 60% may suggest conditions like dehydration or polycythemia. Choices A, C, and D are incorrect because they fall outside the normal range for hematocrit levels in a healthy adult.
A critical role of secondary lymphoid tissues is to:
- A. Provide a place for B and T lymphocytes to mature and begin expression of antigen receptors
- B. Allow co-localization of the components required to activate naïve lymphocytes
- C. Minimize contact of naïve lymphocytes with self antigens
- D. All of the above
Correct Answer: B
Rationale: Step 1: Secondary lymphoid tissues bring together antigen-presenting cells and lymphocytes, facilitating the activation of naïve lymphocytes.
Step 2: Co-localization of these components is essential for efficient immune response initiation.
Step 3: Maturation and expression of antigen receptors primarily occur in primary lymphoid tissues, not secondary.
Summary:
A: Incorrect. Maturation of lymphocytes occurs mainly in primary lymphoid tissues.
C: Incorrect. Contact with self-antigens is necessary for self-tolerance and occurs in primary lymphoid tissues.
D: Incorrect. Only choice B accurately describes the critical role of secondary lymphoid tissues.
TLRs contain a cytoplasmic TIR domain also found in the receptor of
- A. Type I Interferons
- B. IL-1β
- C. TNF-α
- D. IL-8
Correct Answer: B
Rationale: Step-by-step rationale for Choice B (IL-1β) being correct:
1. The TIR domain is present in Toll-like receptors (TLRs) and IL-1 receptor.
2. TLRs recognize various microbial products, while IL-1 receptor binds IL-1 cytokines.
3. Both TLRs and IL-1 receptor signal through the TIR domain.
4. IL-1β is a cytokine that binds to IL-1 receptor, which contains a TIR domain.
Summary of why the other choices are incorrect:
A: Type I Interferons - Type I interferons signal through JAK-STAT pathway, not TIR domain.
C: TNF-α - TNF receptor family signals through TNF receptor-associated death domain, not TIR domain.
D: IL-8 - IL-8 binds to CXCR1 and CXCR2 receptors, which do not contain a TIR domain.
In summary, Choice B
Why did Barry Marshall drink a pure culture of Helicobacter pylori?
- A. To demonstrate the H. pylori is the cause of gastric cancer
- B. To demonstrate an association between H. pylori infection and gastric ulcers
- C. To demonstrate that gastric ulcers are caused by stress rather than bacterial
- D. A and B are both correct
Correct Answer: B
Rationale: Barry Marshall drank a pure culture of H. pylori to demonstrate an association between H. pylori infection and gastric ulcers. This is because he wanted to prove the theory that the bacteria is a primary cause of stomach ulcers, contradicting the prevailing belief at the time. Choice A is incorrect because the direct link between H. pylori and gastric cancer was not the primary focus of his experiment. Choice C is incorrect as his goal was to show the bacterial link to ulcers, not to disprove stress as a factor. Choice D is incorrect because only choice B accurately reflects his intended purpose.