Nokea
Selective β2 agonists produce all of the following EXCEPT:
- A. Stimulate β2 > β1
- B. Bronchodilation
- C. Decrease of blood pressure
- D. Stimulate uterine contraction
Correct Answer: D
Rationale: The correct answer is D: Stimulate uterine contraction. Selective β2 agonists primarily target β2 receptors in the lungs, leading to bronchodilation. They have minimal effect on β1 receptors, thus do not significantly impact heart rate or blood pressure. However, β2 receptors in the uterus can cause uterine relaxation, not contraction. Therefore, selective β2 agonists do not stimulate uterine contractions. Choices A, B, and C are incorrect as they align with the typical effects of selective β2 agonists.
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Alpha methyl dopa can produce:
- A. Inhibition of decarboxylase enzyme
- B. Increases renin
- C. Stimulation of Alpha2 receptor centrally
- D. Decreases blood pressure
Correct Answer: D
Rationale: Step 1: Alpha methyl dopa is a centrally acting antihypertensive medication.
Step 2: It is a prodrug that is converted to alpha-methyl norepinephrine in the brain.
Step 3: This metabolite stimulates alpha2 receptors in the brain, leading to decreased sympathetic outflow.
Step 4: Decreased sympathetic outflow results in decreased peripheral vascular resistance and ultimately decreases blood pressure.
Summary: Option D is correct because alpha methyl dopa decreases blood pressure by acting centrally on alpha2 receptors. Options A, B, and C are incorrect as alpha methyl dopa does not inhibit decarboxylase enzyme, increase renin, or stimulate alpha2 receptors centrally.
Donepezil is a reversible anti-cholinesterase used in the treatment of:
- A. Glaucoma
- B. Bradycardia
- C. Urine retention
- D. Alzheimer disease
Correct Answer: D
Rationale: Donepezil is used in the treatment of Alzheimer's disease because it is a reversible anti-cholinesterase that helps improve cognitive function by increasing levels of acetylcholine in the brain. This neurotransmitter is important for memory and learning, which are affected in Alzheimer's disease.
Choice A (Glaucoma) is incorrect because Donepezil does not treat this condition. Choice B (Bradycardia) is incorrect because Donepezil does not affect heart rate. Choice C (Urine retention) is incorrect because Donepezil does not have any impact on urinary function.
In summary, the correct answer is D (Alzheimer's disease) because Donepezil's mechanism of action aligns with the cognitive deficits seen in this condition, while the other choices are not related to the drug's pharmacological effects.
If you drank a liter of water very quickly, the result would be
- A. increased secretion of oxytocin
- B. decreased secretion of antidiuretic hormone
- C. decreased secretion of oxytocin
- D. increased secretion of antidiuretic hormone
Correct Answer: B
Rationale: The correct answer is B: decreased secretion of antidiuretic hormone. When you drink a liter of water quickly, it leads to a sudden increase in blood volume and a decrease in blood osmolality. This triggers the body to reduce the secretion of antidiuretic hormone (ADH) to prevent excessive water retention and maintain proper fluid balance. ADH helps in water reabsorption in the kidneys, so decreased secretion allows for more water to be excreted through urine. The other choices are incorrect because drinking water rapidly would not directly affect oxytocin secretion.
The left supra-renal vein drains into:
- A. Inferior vena cava
- B. Inferior mesenteric vein
- C. Left renal vein
- D. Superior mesenteric vein
Correct Answer: C
Rationale: The left supra-renal vein drains into the left renal vein. This is because the left adrenal gland is located above the left kidney, and the left renal vein is responsible for draining blood from the left kidney and adjacent structures, including the left adrenal gland. Therefore, the correct answer is C.
Incorrect options:
A: The inferior vena cava receives blood from various veins in the body but not specifically from the left supra-renal vein.
B: The inferior mesenteric vein drains the large intestine and does not receive blood from the left supra-renal vein.
D: The superior mesenteric vein drains blood from the small intestine and does not receive blood from the left supra-renal vein.
In summary, the left supra-renal vein drains into the left renal vein due to their anatomical proximity, making option C the correct answer.
“Sugar, salt, and sex†is descriptive of
- A. ACTH, TSH, and somatotropic hormone.
- B. cortisol, aldosterone, and testosterone.
- C. epinephrine, norepinephrine, and estrogen.
- D. insulin, glucagon, and cortisol.
Correct Answer: B
Rationale: The correct answer is B: cortisol, aldosterone, and testosterone. "Sugar, salt, and sex" refers to hormones produced by the adrenal glands. Cortisol regulates sugar metabolism, aldosterone regulates salt balance, and testosterone is involved in sexual characteristics. A: ACTH, TSH, and somatotropic hormone are hormones produced by the pituitary gland. C: Epinephrine, norepinephrine, and estrogen are not directly related to the terms given. D: Insulin, glucagon, and cortisol are involved in glucose regulation, but do not match the specific terms provided.