Nokea
Some top-selling drugs that are currently prescribed to treat certain immune-mediated diseases are actually monoclonal antibodies specific for:
- A. An inflammatory cytokine
- B. An inflammatory cytokine receptor
- C. Lymphocytes of the T cell lineage
- D. Two of these responses are correct
Correct Answer: D
Rationale: The correct answer is D because some top-selling drugs for immune-mediated diseases target either an inflammatory cytokine or its receptor. Monoclonal antibodies specific for an inflammatory cytokine can block its activity, while those targeting the receptor can prevent the cytokine from binding and triggering immune responses. Choices A and B are correct examples of drugs targeting inflammatory pathways. Choice C, targeting T cell lymphocytes, is less common for immune-mediated diseases compared to targeting cytokines or receptors. Therefore, D is the correct answer as it encompasses both common targeting strategies.
You may also like to solve these questions
Which of the following statements is NOT true?
- A. A B cell epitope will often be destroyed by denaturation
- B. A pathogen will often have more than one B cell epitope
- C. A B cell epitope is the part of the antibody molecule that contacts an antigen
- D. B cell epitopes are most commonly found on the surface of pathogens
Correct Answer: C
Rationale: The correct answer is C because a B cell epitope is not a part of the antibody molecule that contacts an antigen. B cell epitopes are specific regions on an antigen that bind to B cell receptors. Choice A is incorrect because denaturation can expose B cell epitopes. Choice B is incorrect because pathogens typically have multiple B cell epitopes. Choice D is incorrect because B cell epitopes can be found on various parts of pathogens, not just on the surface.
What accurately describes passive acquired immunity (select all that apply)?
- A. Pooled gamma globulin
- B. Immunization with antigen
- C. Temporary for several months
- D. Immediate, lasting several weeks
Correct Answer: C
Rationale: Passive acquired immunity involves the transfer of antibodies from one individual to another, such as pooled gamma globulin, maternal immunoglobulins, and immediate protection that lasts for weeks to months.
What cytokine is produced by Regulatory T cells to suppress immune responses?
- A. IL-2
- B. IL-10
- C. IFN-gamma
- D. TNF-alpha
Correct Answer: B
Rationale: The correct answer is B: IL-10. Regulatory T cells produce IL-10 to suppress immune responses by inhibiting the activation and function of other immune cells. IL-2 (A) is mainly produced by activated T cells to promote proliferation. IFN-gamma (C) is produced by T cells and NK cells to enhance immune response. TNF-alpha (D) is produced by macrophages and T cells to induce inflammation. IL-10 stands out as the suppressor cytokine in this context.
Which immune cells are primarily responsible for antibody production?
- A. Neutrophils
- B. Plasma cells (derived from B lymphocytes)
- C. Natural killer cells
- D. Macrophages
Correct Answer: B
Rationale: The correct answer is B: Plasma cells (derived from B lymphocytes). B lymphocytes are responsible for producing antibodies. When activated, B cells differentiate into plasma cells, which are specialized in secreting antibodies. Neutrophils are primarily involved in phagocytosis, not antibody production. Natural killer cells are involved in killing infected cells, not antibody production. Macrophages are phagocytic cells that present antigens to activate B lymphocytes but do not produce antibodies themselves. Therefore, the correct answer is B as plasma cells derived from B lymphocytes are primarily responsible for antibody production.
Which class of biological molecules can be bound by an immunoglobulin?
- A. Proteins
- B. Carbohydrates
- C. Lipids
- D. All of the above
Correct Answer: D
Rationale: The correct answer is D, "All of the above." Immunoglobulins are antibodies produced by the immune system to recognize and bind to foreign molecules called antigens. These antigens can be proteins (choice A), carbohydrates (choice B), or lipids (choice C). Therefore, immunoglobulins can bind to all classes of biological molecules. Choices A, B, and C are incorrect as they each represent individual classes of molecules that can be targeted by immunoglobulins, but the correct answer encompasses all of them.