ATI Pediatrics Test Bank Related

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The bronchospasm and dyspnea are clinical manifestation of organophosphorus poisoning are caused by :

  • A. muscarinic action
  • B. nicotinic action
  • C. CNS action
  • D. all the above
Correct Answer: A

Rationale: The bronchospasm and dyspnea seen in organophosphorus poisoning are primarily caused by the muscarinic action of the toxic substance. Organophosphates inhibit acetylcholinesterase, leading to an excess of acetylcholine at the neuromuscular junctions. This results in overstimulation of muscarinic receptors, causing symptoms such as bronchoconstriction, increased secretions, and respiratory distress. Nicotinic actions primarily lead to muscle weakness and paralysis, while CNS actions can cause seizures and altered mental status. So, in the case of bronchospasm and dyspnea, the muscarinic action is the main contributing factor.