Nokea
The client with gastroesophageal reflux disease (GERD) is being taught about dietary modifications by the nurse. Which instruction should the nurse include?
- A. Increase your intake of spicy foods.
- B. Avoid lying down immediately after eating.
- C. Consume a high-fat diet.
- D. Drink caffeinated beverages with meals.
Correct Answer: B
Rationale: The correct answer is B: Avoid lying down immediately after eating. This instruction helps prevent acid reflux by allowing gravity to aid in digestion. Lying down can cause stomach acid to flow back up the esophagus, exacerbating GERD symptoms. Increasing intake of spicy foods (A) can irritate the esophagus, consuming a high-fat diet (C) can delay stomach emptying and worsen symptoms, and drinking caffeinated beverages with meals (D) can relax the lower esophageal sphincter, leading to more reflux.
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A 35-year-old woman presents with abdominal pain, diarrhea, and weight loss. She has a history of recurrent mouth ulcers and a perianal fistula. What is the most likely diagnosis?
- A. Ulcerative colitis
- B. Irritable bowel syndrome
- C. Crohn's disease
- D. Diverticulitis
Correct Answer: C
Rationale: The most likely diagnosis is Crohn's disease (Choice C). This is supported by the symptoms of abdominal pain, diarrhea, weight loss, mouth ulcers, and perianal fistula, which are characteristic of Crohn's disease. These symptoms are not typically seen in irritable bowel syndrome (Choice B) or diverticulitis (Choice D). While ulcerative colitis (Choice A) may also present with similar symptoms, the presence of perianal fistula and mouth ulcers is more indicative of Crohn's disease. Crohn's disease is a chronic inflammatory condition that can affect any part of the gastrointestinal tract, leading to the diverse range of symptoms seen in this patient.
A 56-year-old woman with rheumatoid arthritis has severe joint pain and swelling in her hands. She has a history of peptic ulcer disease five years ago but presently has no GI symptoms. You elect to start her on an NSAID. Which of the following is correct?
- A. Proton-pump inhibitors and H2-blockers are equally effective in prophylaxis against NSAID-related GI toxicity.
- B. Misoprostol is superior to an H2-blocker in prophylaxis against NSAID-related GI toxicity.
- C. Sucralfate is not the drug of choice for prophylaxis in this patient.
- D. H. pylori infection can alter the risk for an NSAID-induced ulcer.
Correct Answer: B
Rationale: Step 1: Misoprostol is a prostaglandin analog that helps protect the gastric mucosa by increasing mucus production. This mechanism of action makes it effective in preventing NSAID-related GI toxicity.
Step 2: H2-blockers (Choice A) and PPIs are not as effective as misoprostol in preventing NSAID-related GI toxicity.
Step 3: Sucralfate (Choice C) is not as effective as misoprostol in preventing NSAID-related GI toxicity due to its different mechanism of action.
Step 4: H. pylori infection (Choice D) can increase the risk of NSAID-induced ulcers but is not directly related to the prophylactic treatment with misoprostol.
A 56-year-old woman presents to discuss the results of her recent upper endoscopy. She was having some mild abdominal pain, so she underwent the procedure, which revealed an ulcer in the antrum of the stomach. Biopsy of the lesion revealed the presence of H. pylori. All of the following statements regarding her condition are correct except
- A. H. pylori has been associated with gastric MALT (mucosa-associated lymphoid tissue)
- B. Reinfection is rare despite adequate treatment
- C. Triple drug therapy has been shown to be more effective than dual drug therapy
- D. If her H. pylori IgG antibody titer was elevated prior to therapy, it can be used to monitor treatment efficacy
Correct Answer: B
Rationale: The correct answer is B: Reinfection is rare despite adequate treatment. H. pylori reinfection can occur, especially in high-prevalence areas or due to poor hygiene. A: Correct - H. pylori is associated with gastric MALT lymphoma. C: Correct - Triple therapy (usually with a proton pump inhibitor, clarithromycin, and amoxicillin) is more effective than dual therapy. D: Correct - H. pylori IgG antibody titer can be used to assess treatment response. Reinfection is not rare and can happen, making option B incorrect.
A 55-year-old man presents with jaundice, pruritus, and dark urine. Laboratory tests reveal elevated bilirubin and alkaline phosphatase. Imaging shows dilated intrahepatic bile ducts and a normal common bile duct. What is the most likely diagnosis?
- A. Primary biliary cirrhosis
- B. Primary sclerosing cholangitis
- C. Gallstones
- D. Pancreatic cancer
Correct Answer: A
Rationale: The most likely diagnosis is Primary biliary cirrhosis (PBC). PBC typically presents with jaundice, pruritus, and dark urine due to impaired bile flow. Elevated bilirubin and alkaline phosphatase levels are common in PBC. Imaging findings of dilated intrahepatic bile ducts and a normal common bile duct support the diagnosis of PBC. Primary sclerosing cholangitis (Choice B) would show strictures and beading of bile ducts on imaging. Gallstones (Choice C) would typically present with a common bile duct obstruction. Pancreatic cancer (Choice D) may present with similar symptoms but is less likely given the specific imaging findings in this case.
A 48-year-old woman presents with fatigue, pruritus, and jaundice. She has a history of ulcerative colitis. Laboratory tests reveal elevated bilirubin and alkaline phosphatase. What is the most likely diagnosis?
- A. Hepatitis B
- B. Primary biliary cirrhosis
- C. Primary sclerosing cholangitis
- D. Autoimmune hepatitis
Correct Answer: C
Rationale: The most likely diagnosis is primary sclerosing cholangitis (PSC) based on the patient's symptoms of fatigue, pruritus, jaundice, and elevated bilirubin and alkaline phosphatase levels. PSC is commonly associated with inflammatory bowel disease, such as ulcerative colitis. The characteristic findings of elevated alkaline phosphatase and bilirubin levels are indicative of cholestasis, which is a key feature of PSC. Additionally, PSC is characterized by fibrosis and inflammation of the bile ducts, leading to bile duct strictures and subsequent liver damage. Hepatitis B would present with viral hepatitis symptoms and different lab findings. Primary biliary cirrhosis typically presents with elevated alkaline phosphatase and antimitochondrial antibodies. Autoimmune hepatitis would have elevated transaminases and autoantibodies. Therefore, based on the clinical presentation and lab results, PSC is the most likely diagnosis.