Nokea
The following drug when used for prolonged period in the maintenance treatment of tonic-clonic seizures can lead to increased metabolism of warfarin like drugs:
- A. Phenobarbitone
- B. Meprobamate
- C. Chlordiazepoxide
- D. Triazolam
Correct Answer: A
Rationale: Phenobarbitone induces CYP450, increasing warfarin metabolism.
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Azathioprine is useful in the following diseases EXCEPT:
- A. Rheumatoid arthritis
- B. Psoriatic arthritis
- C. Reactive arthritis
- D. osteoarthritis
Correct Answer: D
Rationale: Azathioprine is not typically used for osteoarthritis, a degenerative condition.
Robert, age 51 years, has been told by his primary care provider (PCP) to take an aspirin a day. Why would this be recommended?
- A. He has arthritis and this will help with the inflammation and pain
- B. Aspirin has anti-platelet activity and prevents clots that cause heart attacks
- C. Aspirin acidifies the urine and he needs this for prostate health
- D. He has a history of GI bleed, and one aspirin a day is a safe dosage
Correct Answer: B
Rationale: Aspirin's antiplatelet effect reduces cardiovascular risk, a common recommendation for men over 50; arthritis or prostate aren't primary reasons.
What happens in the case of thyroid hormones triiodethyronine (T3) and tetraiodethyronine (T4) I the blood:
- A. Decrease thyrotropin hormone release in the blood
- B. Increase thyrotropin hormone release in the blood
- C. Decrease thyroid releasing hormone release in the blood
- D. Doesn't change thyrotropine and thyroid releasing hormone release
Correct Answer: A
Rationale: High T3 and T4 levels decrease TSH release via negative feedback on the pituitary.
Which of the following is the longest acting newer antihistamine:
- A. Mequitazine
- B. Loratidine
- C. Astemizole
- D. Terfenadine
Correct Answer: C
Rationale: Astemizole has the longest duration among listed antihistamines.
Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
- A. Decreased therapeutic levels of quinidine
- B. Increased therapeutic levels of quinidine
- C. Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination
- D. Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination
Correct Answer: D
Rationale: Quinidine inhibits P-glycoprotein, increasing levels of drugs like digoxin by reducing efflux, not affecting quinidine itself or lowering digoxin .