Nokea
The following drugs are correctly paired with a clinical use EXCEPT:
- A. Danazol to treat endometriosis
- B. Flutamide to treat benign prostatic hyperplasia
- C. Finasteride to treat male pattern baldness
- D. Clomiphene to treat anovulatory infertility
Correct Answer: B
Rationale: Flutamide treats prostate cancer, not BPH; finasteride is used for BPH.
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Which of the following statements about pancreatic enzymes is true?
- A. Dosing may be titrated according to the decrease of steatorrhea
- B. The amount of carbohydrates in the meal drives the amount of enzyme used
- C. The amount of medication used is increased with a cystic fibrosis pulmonary flare
- D. The FDA and Internet-available formulations are bioequivalent
Correct Answer: A
Rationale: Pancreatic enzyme dosing adjusts based on steatorrhea reduction; carbs aren't the driver, and flares don't increase it.
Which of the following avoids first pass effect of drugs
- A. Oral ingestion
- B. Rectal Suppository
- C. Intra venous injection
- D. Intra-arterial injection
Correct Answer: D
Rationale: Intra-arterial injection bypasses the liver, avoiding first-pass metabolism.
Aminoglycosides are poorly absorbed from the gut and must therefore be delivered via parenteral routes.
- A. TRUE
- B. FALSE
Correct Answer: A
Rationale: Aminoglycosides have poor oral bioavailability due to their polar nature, requiring parenteral administration (e.g., IV or IM) for systemic effects.
Under the influence of thyroxin, cholesterol level in the blood:
- A. Increase
- B. Decrease
- C. Does not change
Correct Answer: B
Rationale: Thyroxine lowers cholesterol by increasing its metabolism and excretion.
Jim presents with complaints of 'heartburn' that is minimally relieved with Tums (calcium carbonate) and is diagnosed with gastroesophageal reflux disease (GERD). An appropriate first-step therapy would be:
- A. Omeprazole (Prilosec) twice a day
- B. Ranitidine (Zantac) twice a day
- C. Famotidine (Pepcid) once a day
- D. Metoclopramide (Reglan) four times a day
Correct Answer: B
Rationale: Ranitidine , an H2 blocker, is a standard first-line GERD treatment; PPIs are next-step, and metoclopramide is for motility.