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The following features are more suggestive of biliary atresia rather than neonatal hepatitis in an infant 6 weeks of age:
- A. Hepatomegaly
- B. Prolonged INR (prothrombin time)
- C. Biopsy specimen showed proliferation of bile ductules, periportal fibrosis and bile lakes
- D. HillA scan reveals delayed uptake and excretion of the contrast material
Correct Answer: C
Rationale: Proliferation of bile ductules, periportal fibrosis, and bile lakes on biopsy are hallmark features of biliary atresia.
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Skin lesions characteristically associated with CNS problems:
- A. Dermatitis herpetiformis
- B. Vitiligo
- C. Strawberry angioma on face
- D. Axillary freckling
Correct Answer: D
Rationale: Axillary freckling
Liver failure in children:
- A. Is always chronic in nature
- B. Wilson's disease is a common cause
- C. Leads to failure to thrive
- D. One of the causes is Reye syndrome
Correct Answer: D
Rationale: Reye syndrome is a known cause of acute liver failure in children, often associated with viral infections and aspirin use.
Contributing features to renal osteodystrophy include:
- A. Hypophosphataemia
- B. Hyperparathyroidism
- C. Increased loss of calcium in the kidney
- D. Hypoalbuminaemia
Correct Answer: B
Rationale: Hyperparathyroidism is a key contributor to renal osteodystrophy due to secondary hyperparathyroidism in chronic kidney disease.
A child has been seen by the school nurse for dizziness since the start of the school term. It happens when standing in line for recess and homeroom. The child now reports that she would rather sit and watch her friends play hopscotch because she cannot count out loud and jump at the same time. When the nurse asks her if her chest ever hurts, she says yes. Based on this history, the nurse suspects that she has:
- A. Ventricular septal defect (VSD)
- B. Aortic stenosis (AS)
- C. Mitral valve prolapse
- D. Tricuspid atresia
Correct Answer: B
Rationale: AS can progress and result in exercise intolerance, which may improve with rest.
Regarding IUGR:
- A. GH deficiency is a recognised complication in later life
- B. Abdominal circumference measured by USG is a diagnostic parameter
- C. Perinatal morbidity is higher in asymmetric IUGR
- D. Nutritional factor is the commonest cause of IUGR in the UK
Correct Answer: B
Rationale: Abdominal circumference measured by ultrasound is a key diagnostic parameter for intrauterine growth restriction (IUGR).