The long-term complications seen in thalassemia major are associated to which of the following?
Correct Answer: C
Rationale: Thalassemia major is a genetic disorder characterized by abnormal hemoglobin production. Individuals with thalassemia major require frequent blood transfusions to manage their anemia, leading to iron overload in the body. Over time, this excess iron can accumulate in various organs such as the liver, heart, and endocrine glands, causing damage and dysfunction. This condition is known as hemochromatosis. Long-term complications of hemochromatosis include liver cirrhosis, heart failure, diabetes, and endocrine disorders. Therefore, the long-term complications seen in thalassemia major are primarily associated with hemochromatosis rather than anemia, growth retardation, or splenomegaly.