Nokea
The major disadvantage of celecoxib is:
- A. It is less efficacious compared to non-selective cox-1 inhibitors
- B. It causes more gastrointestinal disturbances
- C. It increases cardiovascular risk of death
- D. It increases risk of kidney disease
Correct Answer: C
Rationale: Celecoxib, a COX-2 inhibitor, increases cardiovascular risk.
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The U.S. Drug Enforcement Administration:
- A. Registers manufacturers and prescribers of controlled substances
- B. Regulates NP prescribing at the state level
- C. Sanctions providers who prescribe drugs off-label
- D. Provides prescribers with a number they can use for insurance billing
Correct Answer: A
Rationale: The DEA registers those handling controlled substances , not state NP rules , off-label sanctions , or insurance numbers .
Niaspan is less likely to cause which side effect that is common to niacin?
- A. Gastrointestinal irritation
- B. Cutaneous flushing
- C. Dehydration
- D. Headaches
Correct Answer: B
Rationale: Niaspan's extended-release form reduces flushing compared to immediate-release niacin.
A nurse is caring for a client who takes Paroxetine to treat PTSD and reports that he grinds his teeth during the night. The nurse should identify which of the following interventions to manage Bruxism? (Select all that apply.)
- A. Concurrent administration of buspirone
- B. Administration of a different SSRI
- C. Use of a mouth guard
- D. Changing to a different class of antidepressant medication
Correct Answer: C
Rationale: A mouth guard is a practical intervention for bruxism; medication changes may not address it directly.
A nurse is planning to administer IV Alteplase to a client who is demonstrating manifestations of a massive Pulmonary Embolism. Which of the following interventions should the nurse plan to take?
- A. Administer IM Enoxaparin along with the Alteplase dose.
- B. Hold direct pressure on puncture sites for up to 30 min.
- C. Administer Aminocaproic acid IV prior to alteplase infusion.
- D. Prepare to administer Alteplase within 8 hr of manifestation onset.
Correct Answer: B
Rationale: Holding pressure prevents bleeding at puncture sites after alteplase, a thrombolytic.
The action of 'gliptins' is different from other antidiabetic agents because they:
- A. Have a low risk for hypoglycemia
- B. Are not associated with weight gain
- C. Close ATP-dependent potassium channels in the beta cell
- D. Act on the incretin system to indirectly increase insulin production
Correct Answer: D
Rationale: Gliptins enhance incretin activity, boosting insulin secretion without hypoglycemia risk , unlike sulfonylureas .