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The nurse explains that what drug resource book is compiled from package inserts?
- A. Nurse's Drug Guide
- B. Physicians Desk Reference (PDR)
- C. Drug Facts and Comparisons
- D. AMA Drug Evaluations
Correct Answer: B
Rationale: The PDR is a compilation of information found on package inserts. The Nurse's Drug Guide uses more easily understood language and incorporates nursing considerations and patient teaching points. Drug Facts and Comparisons includes cost comparison, often not found in other drug resource guides. The AMA Drug Evaluations is far less biased than the PDR and includes drugs still in the research stage of development.
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Regular intake of small amount of ethanol may
- A. Increase HDL level and LDL oxidation
- B. Decrease HDL level and LDL oxidation
- C. Increase HDL level and decrease LDL oxidation
- D. Decrease synthesis of VLDL
Correct Answer: C
Rationale: Moderate ethanol intake is known to increase HDL (good cholesterol) levels and reduce LDL oxidation, offering some cardiovascular benefit.
A 68-year-old patient who must take antihistamines for severe allergies is planning a vacation to Mexico. The nurse will encourage the patient to:
- A. Avoid sightseeing during the hottest part of the day
- B. Discontinue the antihistamines if he becomes extremely restless
- C. Decrease the dosage of the drugs if he experiences excessive thirst
- D. Continue taking the antihistamines even if he begins to hallucinate
Correct Answer: A
Rationale: Antihistamines can decrease sweating by blocking cholinergic receptors, placing the patient at high risk for heat stroke. Avoiding the hottest part of the day will help prevent dehydration and heat prostration. Extreme restlessness could indicate Parkinson-like syndrome not usually associated with antihistamines. Excessive thirst is characteristic of hyperglycemia, and hallucinations are associated with drugs that affect neurologic functioning. Nurses should never tell patients to decrease or discontinue a drug unless the prescriber has instructed them to do so.
The trial period to determine effective anti-inflammatory activity when starting a patient on aspirin for rheumatoid arthritis is:
- A. 48 hours
- B. 4 to 6 days
- C. 4 weeks
- D. 2 months
Correct Answer: B
Rationale: Aspirin's anti-inflammatory effect for RA takes 4-6 days; 48 hours is too short.
A nurse is assessing the patient's home medication use. After listening to the patient list current medications, the nurse asks what priority question?
- A. Do you take any generic medications?
- B. Are any of these medications orphan drugs?
- C. Are these medications safe to take during pregnancy?
- D. Do you take any over-the-counter medications?
Correct Answer: D
Rationale: It is important for the nurse to specifically question use of over-the-counter medications because patients may not consider them important. The patient is unlikely to know the meaning of orphan drugs unless they too are health care providers. Safety during pregnancy, use of a generic medication, or classification of orphan drugs are things the patient would be unable to answer but could be found in reference books if the nurse wishes to research them.
Which cytochrome is responsible for drug metabolism?
- A. P-450
- B. C-3b
- C. C-3a
- D. C-2a
Correct Answer: A
Rationale: Cytochrome P-450 enzymes in the liver are primary for drug metabolism.