Nokea
The nurse is explaining how medications work to a group of peers and explains that disruption of a single step in any enzyme system disrupts what?
- A. Cell life
- B. Cell membrane
- C. Cell receptor sites
- D. Cell function
Correct Answer: D
Rationale: If a single step in one of the many enzyme systems is blocked, normal cell function is disrupted. Cell life and cell membrane may be impacted by disruption of some enzymes but not all enzymes. Receptor sites would not be disrupted by disruption in a single step in the enzyme system.
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T½ of a drug can determine all the following
- A. Closing interval
- B. Elimination time
- C. Steady Plasma Concentration
- D. Therapeutic dosage
Correct Answer: D
Rationale: Half-life (t½) informs dosing intervals to maintain therapeutic levels.
What is correct concerning TI:
- A. A safer drug has a higher theraputic index
- B. TI might be equal to 1
- C. The more the unwanted adverse effect, the ration decreases
- D. You are in danger if you take 1.8 ng/ml of Digoxin which has the margin of safety (0.8-2)
Correct Answer: A
Rationale: A higher therapeutic index indicates a greater margin of safety between therapeutic and toxic doses, making the drug safer.
A 73-year-old male patient is being discharged home today. The discharge order reads: Take 10 mL of guaifenesin (Robitussin) with plastic measuring caps. How much should the nurse teach the client to take at home?
- A. 1/2 tsp
- B. 1 tsp
- C. 2 tsp
- D. 1 tbsp
Correct Answer: C
Rationale: 10 mL equals 2 teaspoons (1 tsp = 5 mL), the correct household measure for patient teaching.
Which of the following best describes the effect of propylthiouracil on thyroid hormone production?
- A. It blocks the release of thyrotropin-releasing hormone
- B. It inhibits uptake of iodide by thyroid cells
- C. It prevents the release of thyroid hormone from thyroglobulin
- D. It blocks iodination and coupling of tyrosines in thyroglobulin to form thyroid hormones
Correct Answer: D
Rationale: Propylthiouracil blocks iodination and coupling in thyroglobulin, inhibiting thyroid hormone synthesis.
Which of the following is thyroid hormone:
- A. Triiodthironine
- B. Monoiodthirozine
- C. Diiodthirozine
- D. Octaiodthironine
Correct Answer: A
Rationale: Triiodothyronine (T3) is a key thyroid hormone that regulates metabolism, unlike the others which are not primary hormones.