Nokea
Antacids such as calcium carbonate (Tums) can reduce the absorption of which of the following nutrients?
- A. Protein
- B. Calcium
- C. Iron
- D. Vitamin K
Correct Answer: C
Rationale: Calcium carbonate binds to iron, forming insoluble complexes that reduce iron absorption.
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First dose phenomenon is a characteristic side effect on initiation of antihypertensive therapy with
- A. Minoxidil
- B. Clonidine
- C. Metroprolol
- D. Prazosin
Correct Answer: B
Rationale: Clonidine can cause sedation or hypotension after the first dose.
Because of their site of action, bile acid sequestering resins:
- A. Should be administered separately from other drugs by at least 4 hours
- B. May increase the risk for bleeding
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: A
Rationale: Bile acid resins bind drugs in the gut, requiring separation by 4 hours.
The nurse is caring for a patient who had a severe, acute, previously unseen adverse effect of a drug in Phase III testing. The patient asks, After all the testing done on this drug, didn't they know this adverse effect could occur? What is the nurse's best response? (Select one that does not apply.)
- A. Pharmaceutical companies sometimes underreport problems to make more money.
- B. Your response to this medication will be reported to the drug company and the Food and Drug Administration (FDA).
- C. After a drug reaches phase III testing it is considered an accepted drug and will not be recalled.
- D. The pharmaceutical company weighs the benefits of the drug with the severity of adverse effects.
Correct Answer: B
Rationale: When a new and unexpected adverse effect occurs, especially one of a serious nature, it is reported to the drug company who reports it to the FDA immediately. When a large number of people begin using the drug in phase III studies, it is not unusual to identify adverse effects not previously noted. It would be both unprofessional and inaccurate to imply that pharmaceutical companies put profit ahead of patient concern because lawsuits would remove any potential profit if a drug proves harmful. The FDA is responsible for weighing risk versus benefit in deciding whether to allow the drug to move to the next phase of testing. Drugs found to have serious adverse effects can be removed from the market at any time.
Which of the following is a luminal amebecide drug?
- A. Metronidazole
- B. Emtine
- C. Doxycycline
- D. Dicloxinide
Correct Answer: D
Rationale: Diloxanide (likely misspelled as Dicloxinide) is a luminal amebicide used to eradicate cysts of Entamoeba histolytica in the intestinal lumen, unlike metronidazole, which targets systemic infection.
A nurse is teaching a patient about a new prescription for hydrochlorothiazide. Which statement indicates that the patient understands the teaching?
- A. I should increase my potassium intake.
- B. I may experience swelling in my legs.
- C. I need to monitor my blood sugar levels.
- D. I can take this medication any time of the day.
Correct Answer: A
Rationale: Hydrochlorothiazide can cause hypokalemia; increasing potassium intake shows understanding, unlike swelling (opposite effect) or timing flexibility (best in morning).