The nurse is obtaining medication history information from a client with Crohn's disease. What medication would the nurse include when asking what medications the client has taken for suppression of the inflammatory and immune response?
- A. Nonsteroidal anti-inflammatory
- B. Angiotensin-converting enzyme inhibitors (ACE-I)
- C. Diuretics
- D. Corticosteroids
Correct Answer: D
Rationale: The nurse obtains a history of immunizations, recent and past infectious diseases, and recent exposure to infectious diseases. The nurse reviews the client's drug history because certain drugs, such as corticosteroids, suppress the inflammatory and immune responses. Nonsteroidal anti-inflammatory medication does not suppress the inflammatory and immune responses of Crohn's disease. An ACE-I prevents the conversion of angiotensin I to angiotensin II and does not suppress the inflammatory or immune response. Diuretics also do not suppress the immune response but help reduce excess fluid from the kidneys.
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The nurse is caring for a client with a suspected immune system disorder. What test would be ordered if a deficiency or excess of immunoglobulins was suspected?
- A. Protein electrophoresis
- B. Enzyme-linked immunosorbent assay
- C. T-cell and B-cell assays
- D. Plasmapheresis
Correct Answer: A
Rationale: When an immune system disorder is suspected, protein electrophoresis screens for diseases associated with a deficiency or excess of immunoglobulins may be ordered. The other options are incorrect tests to diagnose a deficiency or excess of immunoglobulins.
A client asks the nurse about the importance of taking supplements to maximize immune function. The client is healthy and does not have any medical problems. What is the best information to give to the client?
- A. Instead of taking supplements, eat a lot of fruits and vegetables to maximize immune function.
- B. Adopt a vegetarian diet and omit all meats, and you will maximize immune function.
- C. You should take a variety of vitamin and mineral supplements to maximize immune function.
- D. Eating a moderate diet that is balanced and varied will maximize immune function.
Correct Answer: D
Rationale: Until more is known about nutrient interactions, the best dietary advice to maximize immune function in healthy people is to eat a moderate diet that is balanced and varied. Eating fruits and vegetables and a vegetarian lifestyle may be healthy choices but do not maximize immune function as a balanced diet will.
What type of cytokine will attract neutrophils and monocytes to remove debris?
- A. Lymphokines
- B. Cytotoxic T cells
- C. Suppressor T cells
- D. Regulator T cells
Correct Answer: A
Rationale: Lymphokines, a type of cytokine, attract cells when they detect antigens and direct B-cell lymphocytes to multiply and mature. Cytotoxic T cells bind to invading cells, destroy the targeted invader by altering their cellular membrane and intracellular environment, and stimulate the release of chemicals called lymphokines. Suppressor T cells limit or turn off the immune response in the absence of continued antigenic stimulation. Regulator T cells are made up of helper and suppressor cells.
A client's immune system has the ability to protect itself from external invaders. What type of immune function is present when this occurs?
- A. Immunosuppression
- B. Immunocompetence
- C. An immune response
- D. Immune incompatibility
Correct Answer: B
Rationale: The immune system is a collection of specialized white blood cells and lymphoid tissues that maintain immunocompetence, the ability to cooperatively protect a person from external invaders and the body's own altered cells. Immunosuppression is the opposite and the white blood cells and lymphoid tissue are not able to protect a person from external invaders. An immune response, primarily involves the lymphocytes that are located in blood and lymphoid tissue. Immune incompatibility is not relevant in this situation.
What type of immunoglobulin does the nurse recognize that promotes the release of vasoactive chemicals such as histamine when a client is having an allergic reaction?
- A. IgG
- B. IgA
- C. IgM
- D. IgE
Correct Answer: D
Rationale: IgE promotes the release of vasoactive chemicals such as histamine and bradykinin in allergic, hypersensitivity, and inflammatory reactions. IgG neutralizes bacterial toxins and accelerates phagocytosis. IgA interferes with the entry of pathogens through exposed structures or pathways. IgM agglutinates antigens and lyses cell walls.
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