The nurse is providing education to a pregnant woman whose genetic testing confirms her fetus has Down syndrome. The nurse understands that Down syndrome is an example of which abnormality?
Correct Answer: B
Rationale: The correct answer is B: Abnormality of chromosomal number. Down syndrome is caused by an extra copy of chromosome 21, leading to trisomy 21. This results in characteristic physical features and intellectual disability. Chromosomal translocation (A) involves the swapping of genetic material between chromosomes. Multifactorial monosomy inheritance (C) refers to a combination of genetic and environmental factors leading to the loss of a chromosome. Autosomal-recessive inheritance (D) requires two copies of a mutated gene to be present for the disorder to manifest, which is not the case in Down syndrome.