Nokea
The primary target of the releasing and inhibiting hormones of the hypothalamus is:
- A. Liver & adipose tissue
- B. Gonads
- C. Anterior pituitary
- D. Bone marrow
Correct Answer: C
Rationale: The correct answer is C: Anterior pituitary. Releasing and inhibiting hormones from the hypothalamus act on the anterior pituitary to regulate the secretion of pituitary hormones. This interaction is known as the hypothalamic-pituitary axis. The hormones released by the hypothalamus travel through the hypophyseal portal system to the anterior pituitary, where they stimulate or inhibit the release of specific pituitary hormones. Choices A, B, and D are incorrect because the primary target of hypothalamic releasing and inhibiting hormones is the anterior pituitary, not the liver & adipose tissue, gonads, or bone marrow.
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Which class of oral glucose-lowering agents is most commonly used for people with type 2 diabetes because it reduces hepatic glucose production and enhances tissue uptake of glucose?
- A. Insulin
- B. Meglitinide
- C. Biguanide
- D. Sulfonylurea
Correct Answer: B
Rationale: Biguanides, like metformin, are commonly used because they reduce glucose production in the liver and enhance tissue glucose uptake.
Several hormones are synthesized in the hypothalamus and transported to the anterior pituitary gland. The mechanism of transportation from hypothalamus to anterior pituitary gland is through the ________.
- A. hepatic portal system
- B. general circulatory system
- C. hypophyseal portal system
- D. feedback loop
Correct Answer: C
Rationale: The correct answer is C: hypophyseal portal system. This system involves a direct blood vessel connection between the hypothalamus and the anterior pituitary gland, allowing hormones synthesized in the hypothalamus to be rapidly transported to the anterior pituitary without being diluted in the general circulation. The hepatic portal system (A) involves blood flow from the digestive system to the liver. The general circulatory system (B) would dilute the hormones before reaching the anterior pituitary. A feedback loop (D) is a mechanism that regulates hormone levels but is not the primary mode of transportation between the hypothalamus and anterior pituitary.
Which is INCORRECT regarding nerve supply to the gut?
- A. the blood vessels are known to have enteric, parasympathetic and sympathetic innervation
- B. the myenteric plexus lies between the longitudinal and circular muscle layers
- C. parasympathetic supply is via vagal and sacral nerve
- D. sympathetic supply is often inhibitory on cholinergic postganglionic fibres
Correct Answer: A
Rationale: The correct answer is A because blood vessels in the gut are primarily innervated by sympathetic and parasympathetic fibers, not by enteric nerves. Enteric nerves are confined to the gastrointestinal tract itself and are responsible for regulating gut motility, secretion, and blood flow. Sympathetic innervation typically causes vasoconstriction, while parasympathetic innervation promotes vasodilation. The myenteric plexus (Auerbach's plexus) lies between the longitudinal and circular muscle layers, regulating gut motility. Parasympathetic supply to the gut is mainly through the vagus nerve (cranial nerve X) and sacral nerves (pelvic splanchnic nerves). Sympathetic supply can either be inhibitory or excitatory, but generally, sympathetic fibers are inhibitory on cholinergic postganglionic fibers in the gut.
The patient with adrenal insufficiency is to be discharged taking prednisone 10 mg orally each day. What will you be sure to teach the patient?
- A. Report excessive weight gain or swelling to the physician.
- B. Rapid changes of position may cause hypotension.
- C. A diet with foods high in potassium may be beneficial.
- D. Signs of hypoglycemia may occur while taking this drug.
Correct Answer: B
Rationale: Patients taking prednisone for adrenal insufficiency should be advised that rapid changes of position can lead to hypotension due to the body's decreased ability to regulate blood pressure.
An exophthalmic goiter is a symptom of ______.
- A. Graves disease.
- B. Hashimoto's disease.
- C. myxedema.
- D. acromegaly.
Correct Answer: A
Rationale: Step-by-step rationale:
1. Exophthalmic goiter refers to bulging eyes and enlarged thyroid gland.
2. Graves disease is an autoimmune disorder causing hyperthyroidism, resulting in both symptoms.
3. Hashimoto's disease is an autoimmune disorder causing hypothyroidism, not associated with exophthalmic goiter.
4. Myxedema is severe hypothyroidism but does not typically present with exophthalmic goiter.
5. Acromegaly is caused by excess growth hormone, leading to enlarged hands and feet, not related to exophthalmic goiter.