Nokea
The term 'chemical antagonism' means that:
- A. two drugs combine with one another to form an inactive compound
- B. two drugs combine with one another to form a more active compound
- C. two drugs combine with one another to form a more water soluble compound
- D. two drugs combine with one another to form a more fat soluble compound
Correct Answer: A
Rationale: Chemical antagonism involves a direct chemical interaction rendering the drug inactive, e.g., chelation.
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A nurse is caring for a 77-year-old patient. The nurse plans care for this patient based on the knowledge that the aging process impacts drug therapy in what important way?
- A. Blood volume decreases
- B. Subcutaneous tissue increases
- C. Total body water increases
- D. Muscle mass increase
Correct Answer: A
Rationale: Decreased blood volume in aging affects drug distribution and concentration.
Janice has elevated LDL, VLDL, and triglyceride levels. Niaspan, an extended-release form of niacin, is chosen to treat her hyperlipidemia. Due to its metabolism and excretion, which of the following laboratory results should be monitored?
- A. Serum alanine aminotransferase
- B. Serum amylase
- C. Serum creatinine
- D. Phenylketonuria
Correct Answer: A
Rationale: Niacin can cause hepatotoxicity, requiring ALT monitoring.
For patients taking warfarin, INRs are best drawn:
- A. Monthly throughout therapy
- B. Three times a week throughout therapy
- C. Two hours after the last dose of warfarin to get an accurate peak level
- D. In the morning if the patient takes their warfarin at night
Correct Answer: D
Rationale: Morning INR aligns with evening warfarin dosing for consistent monitoring; monthly is typical later, not peak-driven .
A nurse is teaching a client who has OCD and has a new prescription for Paroxetine. Which of the following instructions should the nurse include?
- A. It can take several weeks before you feel like the medication is helping.
- B. Take the medication just before bedtime to promote sleep.
- C. I should take the medication for a new medical for a excessive urges.
- D. Monitor for weight gain while taking this medication.
Correct Answer: A
Rationale: Paroxetine, an SSRI, takes weeks for full effect , a key point for client expectations.
Prior to prescribing metformin, the provider should:
- A. Draw a serum creatinine to assess renal function
- B. Try the patient on insulin
- C. Tell the patient to increase iodine intake
- D. Have the patient stop taking any sulfonylurea to avoid dangerous drug interactions
Correct Answer: A
Rationale: Metformin requires renal function assessment (creatinine) due to lactic acidosis risk; insulin isn't a prerequisite.