Nokea
Toxoplasma gondii infection in humans causes:
- A. Oral ulcers
- B. Cervical lymphadenopathy
- C. Microcephaly
- D. Chorioretinitis
Correct Answer: D
Rationale: Chorioretinitis is a hallmark of congenital toxoplasmosis, leading to vision impairment.
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An 8-year-old from the former Soviet Union is brought to your office because of a heart murmur and dusty blue skin. He has marked clubbing of his fingers and toes, and his hematocrit is 70%. He has a grade 4/6 holosystolic murmur. His chest x-ray reveals a normal pulmonary blood flow as well as a right-sided aortic arch. What is the likely diagnosis?
- A. total anomalous venous return
- B. tetralogy of Fallot
- C. Eisenmenger syndrome
- D. transposition of the great vessels
Correct Answer: C
Rationale: Eisenmenger syndrome involves reversal of shunt direction due to long-standing pulmonary hypertension, explaining the cyanosis and clubbing.
Which of the following statements is incorrect regarding shock?
- A. In cardiogenic shock systemic vascular resistance is high
- B. In hypovolemic shock pulmonary capillary wedge pressure is reduced
- C. In distributive shock central venous pressure is increased
- D. In hypovolemic shock mean arterial pressure is normal
Correct Answer: D
Rationale: In hypovolemic shock
Which is a major clinical manifestation of rheumatic fever?
- A. Polyarthritis
- B. Osler nodes
- C. Janeway spots
- D. Splinter hemorrhages of distal third of nails
Correct Answer: A
Rationale: Polyarthritis, which is swollen, hot, red, and painful joints, is a major clinical manifestation of rheumatic fever. The affected joints will change every 1 to 2 days. Primarily the large joints are affected. Osler nodes, Janeway spots, and splinter hemorrhages are characteristic of infective endocarditis.
One of the following is a characteristic physical finding in patients with an ASD
- A. a right precordial bulge
- B. a fixed splitting of the second heart sound
- C. a systolic ejection heart murmur
- D. a short, mild left mid-diastolic murmur
Correct Answer: B
Rationale: Fixed splitting of the second heart sound is a hallmark of an atrial septal defect.
What is ONE gene mutation typically associated with Marfan’s syndrome?
- A. FBN1
- B. ACTA2
- C. SIX2
- D. TGFBR2
Correct Answer: A
Rationale: The FBN1 mutation is the most commonly identified genetic mutation associated with Marfan's syndrome.