Nokea
Under the influence of thyroxin, cholesterol level in the blood:
- A. Increase
- B. Decrease
- C. Does not change
Correct Answer: B
Rationale: Thyroxine lowers cholesterol by increasing its metabolism and excretion.
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Which of the following statements about pancreatic enzymes is true?
- A. Dosing may be titrated according to the decrease of steatorrhea
- B. The amount of carbohydrates in the meal drives the amount of enzyme used
- C. The amount of medication used is increased with a cystic fibrosis pulmonary flare
- D. The FDA and Internet-available formulations are bioequivalent
Correct Answer: A
Rationale: Pancreatic enzyme dosing adjusts based on steatorrhea reduction; carbs aren't the driver, and flares don't increase it.
Beta blocker which has less first pass metabolism and more excretion through kidney is
- A. Propranolol
- B. Sotalol
- C. Bisprolol
- D. Nadolol
Correct Answer: B
Rationale: Sotalol has minimal first-pass metabolism and is excreted renally.
The following drugs are correctly paired with a clinical use EXCEPT:
- A. Danazol to treat endometriosis
- B. Flutamide to treat benign prostatic hyperplasia
- C. Finasteride to treat male pattern baldness
- D. Clomiphene to treat anovulatory infertility
Correct Answer: B
Rationale: Flutamide treats prostate cancer, not BPH; finasteride is used for BPH.
A nurse is preparing a teaching plan for a female client who has Bipolar disorder and a new prescription for Carbamazepine. Which of the following instructions should the nurse include in the teaching? (Select one that does not apply.)
- A. This medication can safely be taken during pregnancy.
- B. Eliminate grapefruit juice from your diet.
- C. You will need to have a complete blood count and carbamazepine levels drawn periodically.
- D. You'll your provider if you develop a rash.
Correct Answer: A
Rationale: Grapefruit juice interacts, blood counts monitor toxicity, rash signals reaction, and driving caution addresses sedation.
The patient has a diagnosis of multiple sclerosis and is taking the drug interferon beta-1a (Rebif). The patient takes this drug by subcutaneous injection three times a week. The dosage is 44 mcg per injection. If the patient takes an injection on Monday, how much of the drug would still be in the patient's system when she takes her next injection on Wednesday, assuming the half-life of the drug is 24 hours?
- A. 22 mcg
- B. 16.5 mcg
- C. 11 mcg
- D. 5.5 mcg
Correct Answer: C
Rationale: The half-life of a drug is the time it takes for the amount of drug in the body to decrease to 1 half the peak level it previously achieved. On Tuesday, there would be 22 mcg remaining in the body, so option A is incorrect. On Wednesday 11 mcg would remain, so option C is the correct answer. At 12 hours before taking the next dose on Wednesday, there would be 16.5 mcg remaining. If the injection were not taken on Wednesday, 12 hours after the dose was due, there would be 5.5 mcg remaining.