What is the risk the fetus will be affected?
Correct Answer: B
Rationale: Spinal muscular atrophy (SMA) type 2 is autosomal recessive. If the mother’s new partner is a carrier (assuming population risk isn’t specified), the risk is 1 in 4 (Choice B): 25% chance the fetus inherits two mutated SMN1 alleles (50% from each carrier parent). 1 in 2 (Choice A) applies if one parent is affected. 1 in 50 (Choice C) or 1 in 200 (Choice D) suggest unrelated carrier frequencies, not applicable without data. 1 in 4 is standard for recessive inheritance with two carriers.
Nokea