Nokea
What takes up a large amount of drug?
- A. Muscles
- B. Adipose
- C. Brain
- D. A and B
Correct Answer: D
Rationale: Muscles and adipose tissue take up large drug amounts due to their mass and lipid content (for lipophilic drugs), respectively, making D correct.
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Sadie is a 72-year-old patient who takes omeprazole for her chronic GERD. Chronic long-term omeprazole use places her at increased risk for:
- A. Megaloblastic anemia
- B. Osteoporosis
- C. Hypertension
- D. Strokes
Correct Answer: B
Rationale: Chronic PPI use like omeprazole reduces calcium absorption, increasing osteoporosis risk; anemia is less direct.
During which phase of pharmacokinetics could a significant drug-drug interaction occur, resulting in one drug stimulating or blocking the metabolism of the other drug?
- A. Absorption
- B. Distribution
- C. Biotransformation
- D. Excretion
Correct Answer: C
Rationale: During biotransformation, a drug may be metabolized quicker if taken at the same time as another drug, and higher doses of the drug will be needed to achieve the desired effect. During absorption, one drug can prevent or accelerate absorption of the other drug. During distribution, one drug competes for the protein-binding site of another drug so the second drug cannot be transported to the reactive tissue. During excretion, one drug competes for excretion with the other drug, leading to accumulation and toxic effects of one of the drugs.
Before administering a prescription medication, what information does the nurse find on the drug label? (Select one that does not apply.)
- A. Brand name
- B. Generic name
- C. Drug concentration
- D. Adverse effects
Correct Answer: D
Rationale: Prescription drug labels will contain the brand name, generic name, drug concentration, and expiration date. Adverse effects will not be listed on drug labels.
A 7-year-old male fell off a wood pile while playing. He has been admitted to the ICU with multiple broken bones and internal bleeding. What should the nurse know about drug therapy in this type of patient?
- A. Adverse effects may be decreased
- B. Therapeutic effects may be increased
- C. Pharmacodynamics may be altered
- D. Pharmacokinetics remain the same
Correct Answer: C
Rationale: Trauma alters pharmacodynamics (drug effects) due to physiological stress and injury responses.
Licorice root is a common treatment for dyspepsia. Drug interactions with licorice include:
- A. Antihypertensives, diuretics, and digoxin
- B. Antidiarrheals, antihistamines, and omeprazole
- C. Penicillin antibiotic class and benzodiazepines
- D. None of the above
Correct Answer: A
Rationale: Licorice affects potassium levels and blood pressure, interacting with antihypertensives, diuretics, and digoxin.