Practice Questions for Respiratory System Related

Review Practice Questions for Respiratory System related questions and content

When Bohr effect occurs due to increased CO2 tension, Oxygen affinity of Hb decreases. The reason for increased CO2 tension is

  • A. Increase in P50
  • B. Decrease in P50
  • C. High CO2 content
  • D. High O2 content
Correct Answer: A

Rationale: The correct answer is A because an increase in P50 indicates a decrease in oxygen affinity of hemoglobin (Hb), as seen in the Bohr effect. When CO2 tension rises, it forms carbonic acid in the blood, leading to a decrease in pH. This decrease in pH causes a right shift in the oxygen-hemoglobin dissociation curve, resulting in lower oxygen affinity of Hb. Decreasing P50 reflects this reduced affinity. Choices B, C, and D are incorrect because a decrease in P50, high CO2 content, and high O2 content would not lead to a decrease in oxygen affinity as observed in the Bohr effect.