Nokea
Where are large fenestrations or slit junctions located?
- A. Bone
- B. Brain
- C. Skin
- D. Liver
Correct Answer: D
Rationale: The liver has large fenestrations in sinusoidal endothelium, allowing easy drug passage, unlike the brain (tight junctions) or bone/skin (less permeable).
You may also like to solve these questions
A nurse is preparing a teaching plan for a female client who has Bipolar disorder and a new prescription for Carbamazepine. Which of the following instructions should the nurse include in the teaching? (Select one that does not apply.)
- A. This medication can safely be taken during pregnancy.
- B. Eliminate grapefruit juice from your diet.
- C. You will need to have a complete blood count and carbamazepine levels drawn periodically.
- D. You'll your provider if you develop a rash.
Correct Answer: A
Rationale: Grapefruit juice interacts, blood counts monitor toxicity, rash signals reaction, and driving caution addresses sedation.
Which of the following avoids first pass effect of drugs
- A. Oral ingestion
- B. Rectal Suppository
- C. Intra venous injection
- D. Intra-arterial injection
Correct Answer: D
Rationale: Intra-arterial injection bypasses the liver, avoiding first-pass metabolism.
After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as the site for the metabolism of most drugs?
- A. Liver
- B. Lungs
- C. Kidneys
- D. Intestinal mucosa
Correct Answer: A
Rationale: Although the kidneys, lungs, plasma, and intestinal mucosa may aid in the metabolism of drugs, most drugs are metabolized by the liver.
Aminoglycosides are poorly absorbed from the gut and must therefore be delivered via parenteral routes.
- A. TRUE
- B. FALSE
Correct Answer: A
Rationale: Aminoglycosides have poor oral bioavailability due to their polar nature, requiring parenteral administration (e.g., IV or IM) for systemic effects.
A nurse is providing teaching to a client who has a new prescription for Digoxin. The nurse should instruct the client to monitor and report which of the following adverse effects that is a manifestation Digoxin toxicity? (Select one that does not apply.)
- A. Fatigue
- B. Constipation
- C. Anorexia
- D. Diplopia
Correct Answer: B
Rationale: Fatigue , anorexia , and diplopia are signs of digoxin toxicity.