Nokea
Which drug reference contains drug monographs that describe all drugs in a therapeutic class?
- A. Drug Facts and Comparisons
- B. Drug Interaction Facts
- C. Handbook on Injectable Drugs
- D. Martindale-The Complete Drug Reference
Correct Answer: A
Rationale: Drug Facts and Comparisons contains drug monographs that describe all drugs in a therapeutic class. Monographs are formatted as tables to allow comparison of similar products, brand names, manufacturers, cost indices, and available dosage forms.
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Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
- A. Decreased therapeutic levels of quinidine
- B. Increased therapeutic levels of quinidine
- C. Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination
- D. Increased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination
Correct Answer: D
Rationale: Quinidine inhibits P-glycoprotein, increasing levels of drugs like digoxin by reducing efflux, not affecting quinidine itself or lowering digoxin .
The patient is taking a drug that affects the body by increasing cellular activity. Where does this drug work on the cell?
- A. Receptor sites
- B. Cell membrane
- C. Golgi body
- D. Endoplasmic reticulum
Correct Answer: A
Rationale: Many drugs are thought to act at specific areas on cell membranes called receptor sites. After the receptor site is activated, this in turn activates the enzyme systems to produce certain effects, such as increased or decreased cellular activity, changes in cell membrane permeability, or alterations in cellular metabolism. Receptor sites are generally located on the outside of cells and allow the drug to bypass the cell membrane. The Golgi body and endoplasmic reticulum are not involved in this process.
Which of the following is an insulin effect in the liver:
- A. Inhibition of glycogenolisis
- B. Inhibition of glycolysis
- C. Decrease of glycogenesis
- D. Decreases of pyruvatkinase, phosphofructokinase and glucokinase activity
Correct Answer: A
Rationale: Insulin inhibits glycogenolysis in the liver, promoting glucose storage as glycogen rather than its breakdown.
A nurse is completing a nursing history for a client who takes Simvastatin. The nurse should identify which of the following disorders as a contraindication to adding Ezetimibe to the client's medications?
- A. History of severe constipation
- B. History of hypertension
- C. Active hepatitis C
- D. Type 2 diabetes mellitus
Correct Answer: C
Rationale: Active hepatitis C contraindicates ezetimibe due to increased liver risk with statins.
Isotonic lactated Ringer's solution is indicated in all of the following conditions EXCEPT:
- A. Dehydration
- B. Liver diseases
- C. Acute blood loss
- D. Lower GIT fluid loss
Correct Answer: B
Rationale: Lactated Ringer's can exacerbate liver disease due to impaired lactate metabolism.