Nokea
Which enzyme is activated by oxidative stress in endothelial cells and plays a key role in the development of complications?
- A. GAPDH
- B. Glyoxalase-1
- C. PARP
- D. Transketolase
Correct Answer: C
Rationale: PARP wakes to oxidative hits repairs DNA, drives damage in diabetes vessels, not GAPDH's stall, glyoxalase's detox, or transketolase's shunt. Nurses clock this, a chronic complication cog.
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Research into people's eating behaviour has produced several findings. Question: Which finding is NOT correct?
- A. When eating in a group, you eat more than when eating alone
- B. Portion size does not influence how much a person eats
- C. Low prices of high-calorie food contribute to overeating
- D. If you eat with people who eat a lot, you will eat more yourself as well
Correct Answer: B
Rationale: Eating truths groups, big portions, cheap junk, piggybacking all pile on, but portion size sways intake, not static. Nurses debunk this, a chronic portion myth.
In the UK, percutaneous cervical cordotomy is likely to be:
- A. Indicated in patients with unilateral pain due to cancer.
- B. Indicated in patients with non-malignant pain.
- C. Effective for neck pain.
- D. Deferred until less invasive techniques have been shown to be unsuccessful.
Correct Answer: A
Rationale: Percutaneous cervical cordotomy (PCC) targets intractable pain in the UK. It's primarily indicated for unilateral cancer pain (e.g., mesothelioma), ablating the contralateral spinothalamic tract for relief below the lesion level. Non-malignant pain rarely justifies PCC due to its invasiveness and risks; alternatives like opioids suffice. Neck pain, above the typical C1-C2 entry, isn't effectively treated by PCC, which addresses lower body pain. CT guidance is common, not just fluoroscopy, for precision. It's a last resort after failed conservative treatments (e.g., nerve blocks), but the cancer-specific indication is primary unilateral pain's anatomical fit with PCC's mechanism (thermoablation) makes it a specialized palliative tool, balancing efficacy with procedural risk.
While a patient is receiving IV doxorubicin hydrochloride for the treatment of cancer, the nurse observes swelling and pain at the IV site. The nurse should prioritize what action?
- A. Stopping the administration of the drug immediately
- B. Notifying the patient's physician
- C. Continuing the infusion but decreasing the rate
- D. Applying a warm compress to the infusion site
Correct Answer: A
Rationale: Doxorubicin's a vesicant swelling and pain scream extravasation, where it leaks into tissue, risking severe necrosis. Stopping the IV stat is priority to limit damage; delaying could worsen injury. Notifying the physician follows, but action comes first. Slowing the infusion keeps pumping toxin into the site disastrous. Warm compresses might spread the drug, unlike ice, which can help post-stoppage per protocol. Nurses must act fast, knowing vesicants like doxorubicin (an anthracycline) demand immediate cessation and often antidotes (e.g., dexrazoxane), critical in oncology to prevent permanent harm from chemo mishaps.
A 3-year-old girl with a Wilms tumor is returning to the unit after a simple nephrectomy. Which of the following actions have the highest priority in caring for this child?
- A. Maintaining NPO.
- B. Monitoring the BP every 2 hours.
- C. Turning her every 2 hours.
- D. Administering pain medication every 4 hours.
Correct Answer: B
Rationale: After a nephrectomy for Wilms tumor, monitoring blood pressure (BP) every 2 hours is the highest priority because kidney removal disrupts renin-angiotensin regulation, risking hypo- or hypertension, especially in a young child with one remaining kidney. Using the ABCs (airway, breathing, circulation), BP falls under circulation, a critical postoperative focus to detect shock or fluid imbalance early. Maintaining NPO is temporary post-anesthesia but shifts to hydration once awake, less urgent than BP. Turning every 2 hours prevents pressure ulcers, but a mobile 3-year-old post-simple nephrectomy likely moves independently unless sedated, lowering its priority. Pain medication is key but ranks lower (e.g., G' in extended ABCs) than circulation. Frequent BP checks ensure stability, aligning with nursing's role in pediatric surgical care to prevent complications in a child adapting to single-kidney function.
Oral glucose tolerance tests (OGTT) are performed in an overweight person , in whom the disturbed glucose tolerance is now diagnosed for the first time, and in a person with normal body weight who shows normal glucose values after oral glucose intake. Question: Which of the following glucose and insulin values, measured one hour after oral glucose intake, are most consistent with these two people?
- A. Glucose 12 mmol/L, Insulin 60 mU/L ; Glucose 8 mmol/L, Insulin 40 mU/L
- B. Glucose 12 mmol/L, Insulin 10 mU/L ; Glucose 8 mmol/L, Insulin 60 mU/L
- C. Glucose 8 mmol/L, Insulin 60 mU/L ; Glucose 4 mmol/L, Insulin 40 mU/L
- D. Glucose 8 mmol/L, Insulin 10 mU/L ; Glucose 4 mmol/L, Insulin 60 mU/L
Correct Answer: A
Rationale: Overweight with new impaired tolerance high glucose, high insulin as fat resists; normal weight, normal test moderate glucose, steady insulin. Twelve and 60 fit the struggler; 8 and 40 the healthy nurses read this, a chronic resistance tale in numbers.